CAS 2002-29-1|Flumethasone 21-pivalate

Introduction：Basic information about CAS 2002-29-1|Flumethasone 21-pivalate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Flumethasone 21-pivalate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles15
7. Synonyms

Common Name	Flumethasone 21-pivalate
CAS Number	2002-29-1	Molecular Weight	494.56800
Density	1.27g/cm3	Boiling Point	600.3ºC at 760mmHg
Molecular Formula	C₂₇H₃₆F₂O₆	Melting Point	/
MSDS	ChineseUSA	Flash Point	316.8ºC
Symbol	GHS08	Signal Word	Warning

Names

Name	flumethasone pivalate
Synonym	More Synonyms

Flumethasone 21-pivalate BiologicalActivity

Description	Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Mandour, A.A., et al. Review on analytical studies of some pharmaceutical compounds containing heterocyclic rings: brinzolamide, timolol maleate, flumethasone pivalate, and clioquinol. Futur J Pharm Sci 6, 52 (2020).

Chemical & Physical Properties

Density	1.27g/cm3
Boiling Point	600.3ºC at 760mmHg
Molecular Formula	C₂₇H₃₆F₂O₆
Molecular Weight	494.56800
Flash Point	316.8ºC
Exact Mass	494.24800
PSA	100.90000
LogP	3.44070
Vapour Pressure	6.51E-17mmHg at 25°C
Index of Refraction	1.55
InChIKey	JWRMHDSINXPDHB-OJAGFMMFSA-N
SMILES	CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(=O)C(C)(C)C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3832010

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-, 21-pivalate

CAS REGISTRY NUMBER :: 2002-29-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H36-F2-O6

MOLECULAR WEIGHT :: 494.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

Safety Information

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R40
Safety Phrases	S22-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU3832010

Articles15

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

[Darkness effect in photochemotherapy. I. Effect of 8-methoxypsoralen on the epidermal patch test in allergic contact eczema].

Dermatol. Monatsschr. 169(1) , 46-8, (1983)

[Double-blind comparison of a betamethasone dipropionate-iodochloroxyquinoline combination and a flumethasone pivalate-iodochloroxyquinoline combination in the therapy of steroid-sensitive dermatoses with superinfection].

G. Ital. Dermatol. Venereol. 121(1) , XI-XIV, (1986)

Synonyms

MFCD00079287

Flumethasone pivalate

Flumethasone 21-Pivalate

[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate

EINECS 217-901-1

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