CAS 514-36-3|Fludrocortisone acetate

Introduction：Basic information about CAS 514-36-3|Fludrocortisone acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fludrocortisone acetate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles28
8. Synonyms

Common Name	Fludrocortisone acetate
CAS Number	514-36-3	Molecular Weight	422.487
Density	1.3±0.1 g/cm3	Boiling Point	575.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₁FO₆	Melting Point	233-234°C
MSDS	ChineseUSA	Flash Point	301.6±30.1 °C
Symbol	GHS07, GHS08	Signal Word	Warning

Names

Name	fludrocortisone acetate
Synonym	More Synonyms

Fludrocortisone acetate BiologicalActivity

Description	Fludrocortisone Acetate is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. It is used to treat Addison's disease by decreasing the amount of sodium that is lost (excreted) in your urine，also used to increase blood pressure.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>Mineralocorticoid ReceptorResearch Areas >>Inflammation/Immunology

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	575.1±50.0 °C at 760 mmHg
Melting Point	233-234°C
Molecular Formula	C₂₃H₃₁FO₆
Molecular Weight	422.487
Flash Point	301.6±30.1 °C
Exact Mass	422.210480
PSA	100.90000
LogP	2.32
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.564
InChIKey	SYWHXTATXSMDSB-GSLJADNHSA-N
SMILES	CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC21C
Storage condition	-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5050000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate

CAS REGISTRY NUMBER :: 514-36-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H31-F-O6

MOLECULAR WEIGHT :: 422.54

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 BF CQ E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,666,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,666,1987

Safety Information

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H361
Precautionary Statements	P280-P301 + P312 + P330
Hazard Codes	Xn: Harmful;
Risk Phrases	R63
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5050000
HS Code	2937229000

Customs

HS Code	2937229000

Articles28

Importance of a suitable working protocol for tape stripping experiments on porcine ear skin: Influence of lipophilic formulations and strip adhesion impairment.

Int. J. Pharm. 491 , 162-9, (2015)

The tape stripping method is a very important tool for dermopharmacokinetic experiments in vitro and the accurate measurement of the removed corneocytes is key for a reliable calculation of a drug's s...

Dilution of semi-solid creams: influence of various production parameters on rheological properties and skin penetration.

Int. J. Pharm. 478(2) , 429-38, (2015)

In order to customise treatment for patients, topical formulations are often diluted with drug-free cream bases to adjust the drug dose and thereby the formulations' activity to the patients' needs. H...

Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity.

Cancer Chemother. Pharmacol. 74(2) , 249-55, (2014)

A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but increased cell proliferation v...

Synonyms

9-Fluoro-11-β,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate

fludrocortisone 21-acetate

9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

Alflorone

Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate

Cortisol, 9-fluoro-, 21-acetate

F-Cortef

Fludrocortisone acetate

2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate

EINECS 208-180-4

Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI)

MFCD00864160

acétate de 2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-diméthyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle

FLORINEF

pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11b)-

2-[(8S,9R,10S,11S,13S,14S,17R)-9-Fluor-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylacetat

(11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate

(11b)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate

Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-

Scherofluron

Fludrocortisone (acetate)

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