Introduction：Basic information about CAS 153808-85-6|Cadrofloxacin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cadrofloxacin |
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| CAS Number | 153808-85-6 | Molecular Weight | 411.37500 |
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| Density | 1.458g/cm3 | Boiling Point | 602.4ºC at 760mmHg |
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| Molecular Formula | C19H20F3N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | 318.1ºC |
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Names
| Name | Cadrofloxacin |
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| Synonym | More Synonyms |
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Cadrofloxacin BiologicalActivity
| Description | Cadrofloxacin (Caderofloxacin; CS-940), a orally active fluoroquinolone, is effective against aerobic/anaerobic Gram-positive and Gram-negative bacteria. Cadrofloxacin can be used for the research of infectious diseases[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Cadrofloxacin against M.tuberculosis with a MIC50 of 0.25 μg/mL[1]. Cadrofloxacin against Acinetobacter spp. and Stenotrophomonas (Xanthomonas) maltophilia with MIC90s of 0.03 and 2 μg/ml, respectively[2]. Cadrofloxacin against Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. with MIC90s less than or equal to 0.06 μg/mL[2]. Cadrofloxacin against members of the family Enterobacteriaceae with MIC90s of 0.015 to 16 μg/mL (median MIC90, 0.06 μg/mL)[2]. |
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| In Vivo | Cadrofloxacin (9 mg/kg; i.g.; once or twice daily for 14 consecutive days) increases the activity of hepatic CYP2E1 in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-220 g[2] Dosage: 9 mg/kg Administration: I.g. once or twice daily for 14 consecutive days Result: Enhanced the expression of hepatic CYP2E1 mRNA, inducing a 1.6-fold increase compared with that of control rats. The level of CYP2E1 protein in the hepatic microsomes was significantly higher than control group, 190% of that in control rats. |
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| References | [1]. Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58. [2]. Biedenbach DJ, et al. Antimicrobial activity of CS-940, a new trifluorinated quinolone. Antimicrob Agents Chemother. 1995 Oct;39(10):2325-30. [3]. Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58. |
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Chemical & Physical Properties
| Density | 1.458g/cm3 |
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| Boiling Point | 602.4ºC at 760mmHg |
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| Molecular Formula | C19H20F3N3O4 |
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| Molecular Weight | 411.37500 |
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| Flash Point | 318.1ºC |
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| Exact Mass | 411.14100 |
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| PSA | 83.80000 |
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| LogP | 2.96700 |
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| Vapour Pressure | 2.33E-15mmHg at 25°C |
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| Index of Refraction | 1.588 |
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| InChIKey | QBDBUKJBJJWZMG-VIFPVBQESA-N |
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| SMILES | CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2OC(F)F)CCN1 |
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Synonyms
| 3-Quinolinecarboxylic acid,1-cyclopropyl-8-(difluoroMethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-Methyl-1-piperazinyl]-4-oxo |
| 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-quinoline-3-carboxylic acid |
| Caderofloxacin |
