CAS 4757-55-5|Dimetacrine

Introduction：Basic information about CAS 4757-55-5|Dimetacrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dimetacrine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Dimetacrine
CAS Number	4757-55-5	Molecular Weight	294.43400
Density	1.015 g/cm3	Boiling Point	406.4ºC at 760mmHg
Molecular Formula	C₂₀H₂₆N₂	Melting Point	/
MSDS	/	Flash Point	180.4ºC

Names

Name	3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine
Synonym	More Synonyms

Dimetacrine BiologicalActivity

Description	Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vivo	Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10 μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3 μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3 mg/kg i.v., and the maximum response is obtained in dose of 3 mg/kg i.v.. The administration of Dimetacrine, 30 mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine[1].
Animal Admin	Adult male mongrel dogs weighing 8 to 13 kg are used and anesthetized with sodium pentobarbital, 35 mg/kg i.v. Respiratory movement is measured by an accordion-type pneumograph placed around the thoraco-abdominal region and a pressure transducer. For the experiments on single i.v. injections, the increasing doses of Dimetacrine, 0.1, 0.3, 1, 3, 10 and 30 mg/kg i.v., until cardiac arrest occurs, are given into the cannulated left cephalic vein and are flushed with 1 mL of physiological saline. The changes in arterial blood pressure and heart rate caused by each dose are estimated for IMP, AMT and Dimetacrine[1].
References	[1]. Kato H, et al. Comparison of cardiovascular toxicities induced by dimetacrine, imipramine and amitriptyline in isolated guinea pig atria and anesthetized dogs. Jpn J Pharmacol. 1974 Dec;24(6):885-91.

Chemical & Physical Properties

Density	1.015 g/cm3
Boiling Point	406.4ºC at 760mmHg
Molecular Formula	C₂₀H₂₆N₂
Molecular Weight	294.43400
Flash Point	180.4ºC
Exact Mass	294.21000
PSA	6.48000
LogP	4.48070
Index of Refraction	1.559
InChIKey	RYQOGSFEJBUZBX-UHFFFAOYSA-N
SMILES	CN(C)CCCN1c2ccccc2C(C)(C)c2ccccc21
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR6973200

CHEMICAL NAME :: Acridan, 9,9-dimethyl-10-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 4757-55-5

BEILSTEIN REFERENCE NO. :: 1349663

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C20-H26-N2

MOLECULAR WEIGHT :: 294.48

WISWESSER LINE NOTATION :: T C666 BM IHJ B3 M1&1 I1 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1076 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1293 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 206 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 676 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,530,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/13W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 91 mg/kg

SEX/DURATION :: male 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,949,1974

Safety Information

HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

Dimetacrinum

Dimetacrinum [INN-Latin]

Dimetacrine

Dimethacrine

[3-(9,9-dimethyl-9H-acridin-10-yl)-propyl]-dimethyl-amine

Dimetacrina [DCIT]

10-(8-Dimethylaminopropyl)-5,5-dimethylacridan

Dimetacrine [INN]

10-(3-Dimethylaminopropyl)-5,5-dimethylacridan

Dimetacrino

Dimethacrin

9,9-Dimethyl-N-<3-(dimethyl-amino)-propyl>-acridan

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