Introduction：Basic information about CAS 66529-17-7|Midaglizole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Midaglizole |
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| CAS Number | 66529-17-7 | Molecular Weight | 251.32600 |
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| Density | 1.14g/cm3 | Boiling Point | 460ºC at 760 mmHg |
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| Molecular Formula | C16H17N3 | Melting Point | / |
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| MSDS | / | Flash Point | 232ºC |
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Names
| Name | Midaglizole |
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| Synonym | More Synonyms |
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Midaglizole BiologicalActivity
| Description | Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Metabolic Disease |
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| In Vitro | Midaglizole stimulates insulin release with the EC50 values of 200 nM, 24 µM for rat islets and MIN6 β-cell line, respectively[3]. |
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| In Vivo | Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats[1]. Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags[2]. Animal Model: 290-450 g, Male Wistar rats[1] Dosage: 3, 30 mg/kg Administration: I.v. Result: Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively. Animal Model: Dogs[2] Dosage: 0.2, 1, 2 mg/kg Administration: Superior pancreaticoduodeneal artery infusion Result: Reduced blood glucose levels by stimulating insulin release from the pancreatic islets. |
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| References | [1]. Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20. [2]. Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19(2):127-32. [3]. Proks P, et al. Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. |
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Chemical & Physical Properties
| Density | 1.14g/cm3 |
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| Boiling Point | 460ºC at 760 mmHg |
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| Molecular Formula | C16H17N3 |
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| Molecular Weight | 251.32600 |
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| Flash Point | 232ºC |
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| Exact Mass | 251.14200 |
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| PSA | 37.28000 |
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| LogP | 2.36970 |
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| Index of Refraction | 1.629 |
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| InChIKey | TYZQFNOLWJGHRZ-UHFFFAOYSA-N |
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| SMILES | c1ccc(C(CC2=NCCN2)c2ccccn2)cc1 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-[2-(2-Imidazolin-2-yl)-1-phenylethyl]pyridine |
| 2-[2-Phenyl-2-(pyridyl)]ethyl-2-imidazolin |
| 2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-1-[2]pyridyl-ethane |
| 4,5-Dihydro-2-[2-(2-pyridinyl)-2-phenylethyl]-1H-imidazole |
| DG-5128 |
| 2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenyl-1-[2]pyridyl-aethan |
| 2-(2-phenyl-2-(2-pyridyl))ethyl-2-imidazoline |
