CAS 103475-41-8|Tepoxalin

Introduction：Basic information about CAS 103475-41-8|Tepoxalin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tepoxalin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Tepoxalin
CAS Number	103475-41-8	Molecular Weight	385.844
Density	1.3±0.1 g/cm3	Boiling Point	573.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀ClN₃O₃	Melting Point	/
MSDS	/	Flash Point	300.3±32.9 °C

Names

Name	tepoxalin
Synonym	More Synonyms

Tepoxalin BiologicalActivity

Description	Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile[1].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>Metabolic Enzyme/Protease >>5-Lipoxygenase
References	[1]. Argentieri DC, et al. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther. 1994 Dec;271(3):1399-408.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	573.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀ClN₃O₃
Molecular Weight	385.844
Flash Point	300.3±32.9 °C
Exact Mass	385.119324
PSA	67.59000
LogP	3.84
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.610
InChIKey	XYKWNRUXCOIMFZ-UHFFFAOYSA-N
SMILES	COc1ccc(-n2nc(CCC(=O)N(C)O)cc2-c2ccc(Cl)cc2)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8002500

CHEMICAL NAME :: 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me thyl-

CAS REGISTRY NUMBER :: 103475-41-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H20-Cl-N3-O3

MOLECULAR WEIGHT :: 385.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1085 mg/kg/31D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 54600 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

Synonyms

Zubrin

Tepoxalinum [Latin]

3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide

1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-

5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide

Tepoxalin

Tepoxalin [USAN:INN]

Tepoxaline

Tepoxalina [Spanish]

Tepoxalina

3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide

3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide

Tepoxaline [French]

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