CAS 7361-31-1|alpha-methyl-dl-tyrosine methyl ester hydrochloride

Introduction：Basic information about CAS 7361-31-1|alpha-methyl-dl-tyrosine methyl ester hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles26
8. Synonyms

Common Name	alpha-methyl-dl-tyrosine methyl ester hydrochloride
CAS Number	7361-31-1	Molecular Weight	245.70300
Density	/	Boiling Point	336.4ºC at 760 mmHg
Molecular Formula	C₁₁H₁₆ClNO₃	Melting Point	192 °C (dec.)(lit.)
MSDS	USA	Flash Point	157.2ºC

Names

Name	methyl 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoate,hydrochloride
Synonym	More Synonyms

BiologicalActivity

Description	α-Methyltyrosine methyl ester hydrochloride is a competitive tyrosine hydroxylase inhibitor that inhibits the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44.

Chemical & Physical Properties

Boiling Point	336.4ºC at 760 mmHg
Melting Point	192 °C (dec.)(lit.)
Molecular Formula	C₁₁H₁₆ClNO₃
Molecular Weight	245.70300
Flash Point	157.2ºC
Exact Mass	245.08200
PSA	72.55000
LogP	2.32740
InChIKey	OOVDEPZODSXAMU-UHFFFAOYSA-N
SMILES	COC(=O)C(C)(N)Cc1ccc(O)cc1.Cl
Storage condition	−20°C
Water Solubility	H2O: 50 mg/mL, clear, faintly yellow

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2900000

CHEMICAL NAME :: p-Tyrosine, alpha-methyl-, methyl ester, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 7361-31-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N-O3.Cl-H

MOLECULAR WEIGHT :: 245.73

WISWESSER LINE NOTATION :: QR D1XZ1&VO1 &GH, -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YP2900000
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles26

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.

Br. J. Pharmacol. 141(1) , 132-40, (2004)

1. The ORL1 agonists nociceptin and Ro 64-6198 were compared in their ability to modify spontaneous locomotor activity in male NMRI mice not habituated to the test environment. 2. Higher doses of noci...

Synonyms

MFCD00012606

EINECS 230-900-0

AMPT

2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride

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