Introduction：Basic information about CAS 109292-46-8|H-Arg-Gly-Asp-Cys-OH trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Arg-Gly-Asp-Cys-OH trifluoroacetate salt |
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| CAS Number | 109292-46-8 | Molecular Weight | 449.48300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C15H27N7O7S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | h-arg-gly-asp-cys-oh |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding. |
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| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Others |
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| In Vitro | RGDC immobilizes peptide onto DAH-CMTMC is found to be about 15.3 μg/mg of chitosan derivative by amino acid analysis (AAA). RGDC-functionalized chitosan may lead to enhanced wound healing (viability >140%). RGDC-functionalizes chitosan derivatives exhibit in vitro wound healing properties by enhancing fibroblast proliferation and adhesion. RGDC-DAH-CMTMC favors cell growth and an increase in cellular proliferation compared to the control cells[1]. |
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| Cell Assay | Human precursor dermal fibroblasts (HDF, human dermal progenitor cells, 12 week male donor) are use in the assay. WST-1 assay is used to assess the viability of HDF when incubated with chitosan derivatives. For this study, HDF are seeded in a 96-well plate at a density of 6×103 cells/cm2. To each well, 100 μL of cell suspension is added and incubated for 48 h in order to allow cell attachment. DMEM is then replaced by 100 μL of CMTMC and RGDC-DAH-CMTMC suspension at concentrations of 0.25 mg/mL, 0.5 mg/mL and 1 mg/mL, respectively. Cell viability under polymer incubation is evaluated during 2, 4 and 7 days. SDS (1%) is used as negative control. The polymer solution is changed every 3 days. 100 μL of WST-1 (1:10 dilution in DMEM) are added in each well after removing the polymer suspension and incubated for 0.5-2 h. Absorbance is recorded with a BioTek Microplate reader at two different wavelengths (450 and 690 nm). The viability is presented as percentage compared to the positive control group (cells in DMEM supplemented with 10% fetal calf serum). All experiments are carried out in triplicates. |
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| References | [1]. Patrulea V, et al. Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing. Carbohydr Polym. 2016 May 20;142:114-23. |
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Chemical & Physical Properties
| Molecular Formula | C15H27N7O7S |
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| Molecular Weight | 449.48300 |
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| Exact Mass | 449.16900 |
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| PSA | 288.62000 |
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| InChIKey | AEGSIYIIMVBZQU-CIUDSAMLSA-N |
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| SMILES | NC(N)=NCCCC(N)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CS)C(=O)O |
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| Storage condition | 2-8℃ |
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Synonyms
| ARG-GLY-ASP-CYS |
| REF DUPL: H-Arg-Gly-Asp-Cys-OH |
| RGDC |
| R-G-D-C |
