CAS 85490-53-5|Motilin (canine)

Introduction：Basic information about CAS 85490-53-5|Motilin (canine), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMotilin (canine)
CAS Number85490-53-5Molecular Weight2685.05000
Density/Boiling Point/
Molecular FormulaC120H194N36O34Melting Point/
MSDS/Flash Point/

Names

NameMotilin canine
SynonymMore Synonyms

Motilin (canine) BiologicalActivity

DescriptionMotilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseasePeptides
In VivoMotilin is a potent agonist for gastrointestinal smooth muscle contraction and has been proposed to regulate the onset of phase III of the migrating motor complex (MMC) in dogs and humans. In the dog, but not in the human, Motilin also contracts the gallbladder and sphincter of Oddi and induces pancreatic secretion. Motilin activates L-type Ca2+ channel (IcaL) in canine jejunal circular smooth muscle cells through a G protein-coupled mechanism. At 1 μM, Motilin increases IcaL in canine jejunal circular smooth muscle cells by 43±20[1].
References

[1]. Farrugia G, et al. Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle. Am J Physiol. 1997 Aug;273(2 Pt 1):G404-12.

Chemical & Physical Properties

Molecular FormulaC120H194N36O34
Molecular Weight2685.05000
Exact Mass2683.46000
PSA1177.80000
LogP4.28950
InChIKeyUXNMKJPZQNQTMI-CSRYRKIZSA-N
SMILESCCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)Cc1ccccc1)C(C)C)C(C)CC)C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)O

Synonyms

Motilin
Motilin, canine
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