CAS 104486-69-3|[Pro9]-Substance P

Introduction：Basic information about CAS 104486-69-3|[Pro9]-Substance P, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name[Pro9]-Substance P
CAS Number104486-69-3Molecular Weight1387.69000
Density1.43g/cm3Boiling Point/
Molecular FormulaC66H102N18O13SMelting Point/
MSDS/Flash Point/

Names

Namearg-pro-lys-pro-gln-gln-phe-phe-pro-leu-met-nh2
SynonymMore Synonyms

[Pro9]-Substance P BiologicalActivity

Description[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].
Related CatalogSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
Target

NK1:0.93 nM (EC50)

In Vitro[3H][Pro9]-Substance P can be used as a radio ligand for NK- 1 binding sites[1]. [Pro9]-Substance P stimulates inositol phosphate formation with an efficacy only slightly lower than that of SP (EC50 values of 0.93 ± 0.07 and 0.45 ± 0.06 nM, respectively) on primary cultures of newborn mouse cortical glial cells[1].

Chemical & Physical Properties

Density1.43g/cm3
Molecular FormulaC66H102N18O13S
Molecular Weight1387.69000
Exact Mass1386.76000
PSA533.14000
LogP4.61590
Index of Refraction1.669
InChIKeyUFBNSKYNZDUWSN-RZGVDQIZSA-N
SMILESCSCCC(NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(N)=O

Safety Information

WGK Germany3

Synonyms

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
9-L-PROLINE-SUBSTANCE P
substance P,Pro(9)
RPKPQQFFPLM-NH2
[TYR9]-SUBSTANCE P
[Pro9]SP
[PRO9] SUBSTANCE P
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH2
pro(9)-substance
[Pro9]-Substance P
CAS 85916-47-8|Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt
CAS 85490-53-5|Motilin (canine)
Recommended......
CAS 109715-12-0|5-(p-Toluenesu CAS 103626-36-4|9H-Purin-6-ami CAS 1028-40-6|4(1H)-Quinazolin CAS 102185-28-4|4-AMINOPHENYLP CAS 1000340-33-9|3,4-Dibromo-1 CAS 10390-14-4|2β-Hydroxy CAS 104-43-8|4-n-Dodecylphenol CAS 104-40-5|4-Nonylphenol CAS 1035-51-4|3-(4-ETHOXYPHENY CAS 10517-44-9|1,3-Propanediam CAS 10534-86-8|Hexaamminecobal CAS 101646-01-9|3,4-DIFLUORO-5 CAS 1011407-68-3|(R)-3-CHLORO- CAS 1092682-87-5|4-Chloro-3-me CAS 1036260-25-9|3-Aminocyclob CAS 105394-83-0|Decarboxy Cipr CAS 106868-09-1|2,2-DI-N-OCTYL CAS 1005615-47-3|3-(4-BROMO-PY CAS 104775-66-8|2-amino-4-chlo CAS 10569-35-4|2-phenyl-3-(2-t
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP