Introduction：Basic information about CAS 219138-21-3|Ac-Ile-Glu-Thr-Asp-pNA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Ile-Glu-Thr-Asp-pNA |
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| CAS Number | 219138-21-3 | Molecular Weight | 638.624 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 1140.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C27H38N6O12 | Melting Point | / |
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| MSDS | / | Flash Point | 643.7±34.3 °C |
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Names
| Name | ac-ietd-pna |
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| Synonym | More Synonyms |
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Ac-Ile-Glu-Thr-Asp-pNA BiologicalActivity
| Description | Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 1140.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C27H38N6O12 |
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| Molecular Weight | 638.624 |
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| Flash Point | 643.7±34.3 °C |
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| Exact Mass | 638.254761 |
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| PSA | 286.15000 |
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| LogP | 1.27 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| InChIKey | FHURKTIGZAIQGR-BQCLNCLCSA-N |
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| SMILES | CCC(C)C(NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(=O)O)C(=O)Nc1ccc([N+](=O)[O-])cc1)C(C)O |
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Synonyms
| ac-ietd-amc |
| z-ala-ala-asp-afc |
| N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)-L-α-asparagine |
| ac-ile-glu-thr-asp-mca |
| ac-ietd-mca |
| L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)- |
| pase-8 substrate |
| pase-8 substrate i |
| ac-ile-glu-thr-asp-amc |
| ax-ietd-amc |
| granzyme b substrate |
