CAS 71977-09-8|Substance P (free acid)
Introduction：Basic information about CAS 71977-09-8|Substance P (free acid), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Substance P (free acid) | ||
|---|---|---|---|
| CAS Number | 71977-09-8 | Molecular Weight | 1348.61000 |
| Density | 1.41 g/cm3 | Boiling Point | / |
| Molecular Formula | C63H97N17O14S | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | substance p |
|---|---|
| Synonym | More Synonyms |
Substance P (free acid) BiologicalActivity
| Description | Substance P, Free Acid is a native substance P analog, but shows no biological activity of substance P. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Others |
| References | [1]. Patel AB, et al. Substance P (free acid) adopts different conformation than native peptide in DMSO, water and DPPC bilayers. J Biomol Struct Dyn. 2001 Aug;19(1):129-38. |
Chemical & Physical Properties
| Density | 1.41 g/cm3 |
|---|---|
| Molecular Formula | C63H97N17O14S |
| Molecular Weight | 1348.61000 |
| Exact Mass | 1347.71000 |
| PSA | 536.14000 |
| LogP | 4.09310 |
| InChIKey | XHWDVRRNQHMAPE-UHFFFAOYSA-N |
| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(=O)O |
| Storage condition | 2-8℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles5
More Articles| Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids. Int. J. Pept. Protein Res. 41 , 411-414, (1993) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ... | |
| Synthesis of peptides by the solid-phase method. 7. Substance P and analogues. J. Med. Chem. 25 , 64, (1982) Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp... | |
| Biological activity of substance P methyl ester. Mol. Pharmacol. 20 , 457, (1981) |
Synonyms
| H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH |
| RPKPQQFFGLM |
| H-RPKPQQFFGLM-OH |
| RPKPQQFFGLM-OH |
| [Met-OH11] substance P |
| ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET |
| Substance P, free acid |
