CAS 75513-71-2|Bovine adrenal medulla dodecapeptide

Introduction：Basic information about CAS 75513-71-2|Bovine adrenal medulla dodecapeptide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bovine adrenal medulla dodecapeptide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles17
6. Synonyms

Common Name	Bovine adrenal medulla dodecapeptide
CAS Number	75513-71-2	Molecular Weight	1424.63000
Density	/	Boiling Point	/
Molecular Formula	C₆₂H₉₇N₂₁O₁₆S	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	bam-12p
Synonym	More Synonyms

Bovine adrenal medulla dodecapeptide BiologicalActivity

Description	BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>GPCR/G Protein >>CXCRSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorSignaling Pathways >>Immunology/Inflammation >>CXCRResearch Areas >>Neurological Disease
Target	human κ-opioid receptor (hKOR):101 nM (EC50) human κ-opioid receptor (hKOR):6.99 (pEC50) CXCR7:175 nM (EC50)
In Vitro	BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性，IC50 为 15.5 nM[2]。
References	[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8. [2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36. [3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.

Chemical & Physical Properties

Molecular Formula	C₆₂H₉₇N₂₁O₁₆S
Molecular Weight	1424.63000
Exact Mass	1423.71000
PSA	643.16000
LogP	2.50620
InChIKey	LNSYPNFYYCUMEW-ALRMXQJESA-N
SMILES	CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(=O)NCC(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)O)C(C)C
Storage condition	-20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Articles17

Substrate specificity of a novel serine protease from soybean [Glycine max (L.) Merrill].

J. Biochem. 119(6) , 1094-9, (1996)

The substrate specificity of a novel serine protease isolated from soybean seeds, cultivar Keburi, was investigated using various peptide-MCAs and several neuropeptides involving single and paired bas...

Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.

Neurosci. Lett. 61(3) , 267-71, (1985)

The inhibitory activity of several pro-enkephalin A-derived opioid peptides, containing the sequence of Met-enkephalin, was evaluated in two isolated organ preparations sensitive to opioids, the guine...

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.

Biochem. Biophys. Res. Commun. 97 , 1283, (1980)

Synonyms

BOVINE ADRENAL MEDULLA-12P

TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU

H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-OH

Peptide E(1-12)

BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE

BOVINE ANDRENAL MEDULLA DODECAPEPTIDE

YGGFMRRVGRPE

BOVINE ADRENAL MEDULLA DODECAPEPTIDE

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