Introduction：Basic information about CAS 11000-17-2|Vasopressin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Vasopressin |
|---|
| CAS Number | 11000-17-2 | Molecular Weight | 1050.22000 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C43H67N15O12S2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Vasopressin |
|---|
| Synonym | More Synonyms |
|---|
Vasopressin BiologicalActivity
| Description | Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors[1][2][3]. |
|---|
| Related Catalog | Research Areas >>Neurological Disease |
|---|
| Target | Human Endogenous Metabolite |
|---|
| In Vitro | AVP (0.01 nM-1 μM) induces Ca2+ increase in Chinese hamster ovary cells expressing rat or human V1b receptors[2]. |
|---|
| In Vivo | Vasopressin (0.03-0.3 μg/kg; i.p.) potentiates corticotropin release provoked by exogenous corticoliberin and increases corticotropin secretion subsequent to body water loss[2]. Vasopressin (0.001-0.1 mg/kg; i.p.) potently increases adjacent lying, where rats meeting for the first time lie passively next to each other[3]. |
|---|
| References | [1]. Baribeau DA, et, al. Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits. Front Neurosci. 2015 Sep 24;9:335. [2]. Ramos L, et, al. Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor. Neuropsychopharmacology. 2013 Oct;38(11):2249-59. [3]. Gal CSL, et, al. Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30. |
|---|
Chemical & Physical Properties
| Molecular Formula | C43H67N15O12S2 |
|---|
| Molecular Weight | 1050.22000 |
|---|
| Exact Mass | 1049.45000 |
|---|
| PSA | 505.74000 |
|---|
| LogP | 1.50910 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YW8200000
- CHEMICAL NAME :
- Vasopressin
- CAS REGISTRY NUMBER :
- 11000-17-2
- LAST UPDATED :
- 199504
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 220 iu/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,415,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4661 No. of Facilities: 114 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 3153 (estimated) No. of Female Employees: 1738 (estimated)
|
Synonyms
| pituitrin |
| EINECS 200-050-5 |
| VASOPRESSIN ACETATE |
| MFCD03839092 |
| vasophysin |
| leiormone |
| tonephin |
| VASOPRASSIN |
| adh(hormone) |
| pitressin |
