CAS 56-59-7|Felypressin

Introduction：Basic information about CAS 56-59-7|Felypressin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Felypressin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles27
6. Synonyms

Common Name	Felypressin
CAS Number	56-59-7	Molecular Weight	1040.219
Density	1.3±0.1 g/cm3	Boiling Point	1571.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₆H₆₅N₁₃O₁₁S₂	Melting Point	254-257 °C
MSDS	ChineseUSA	Flash Point	904.1±34.3 °C

Names

Name	felypressin
Synonym	More Synonyms

Felypressin BiologicalActivity

Description	Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As.target: Vasopressin 1 agonist;Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures.Felypressin has been widely added to local anesthetic solutions to increase the duration of the anesthetic effect and reduce the risk of toxicity during dental procedures.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease
References	[1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31. [2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.

Description

Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As.target: Vasopressin 1 agonist;Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures.Felypressin has been widely added to local anesthetic solutions to increase the duration of the anesthetic effect and reduce the risk of toxicity during dental procedures.

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease

References

[1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.

[2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	1571.3±65.0 °C at 760 mmHg
Melting Point	254-257 °C
Molecular Formula	C₄₆H₆₅N₁₃O₁₁S₂
Molecular Weight	1040.219
Flash Point	904.1±34.3 °C
Exact Mass	1039.436768
PSA	455.92000
LogP	-5.00
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.574
InChIKey	SFKQVVDKFKYTNA-XDYZDBQGSA-N
SMILES	NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccccc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport

Articles27

Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa.

J. Pharm. Sci. 103(7) , 2053-61, (2014)

The pH partition theory proposes a correlation between fraction of unionized drug substance and permeability. The aim of this study was to compare the permeability of metoprolol and mannitol in ex viv...

Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents.

Cochrane Database Syst. Rev. 12 , CD009742, (2014)

Whilst carrying out dental procedures under general anaesthesia (GA), practitioners routinely give local anaesthetics (LA) intraoperatively to children. Local anaesthetics are used to help manage post...

Octopus, which owns the most advanced brain in invertebrates, has two members of vasopressin/oxytocin superfamily as in vertebrates.

Regul. Pept. 115(2) , 139-49, (2003)

A novel member of the vasopressin/oxytocin superfamily, octopressin (OP), has been isolated from Octopus vulgaris. Since another peptide of this superfamily, cephalotocin (CT), was isolated from the s...

Synonyms

(2-L-Phenylalanine)-8-lysinevasopressin

Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-6,9,12,15,18-pentaoxo-13,16-bis(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-lysyl-

Felypressine

M.W. 1040.22 C46H65N13O11S2

Felypressin Acetate

2-(Phenylalanine)-8-lysine vasopressin

felypressin

[PHE2,LYS8]-VASOPRESSIN

2-(L-Phenylalanine)-8-L-lysinevasopressin

Octapressin

MFCD00868221

PLV-2

2-(phenylalanine)-8-lyine vasopression

Phelypressin

L-Cysteinyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysylglycinamide cyclic (1®6)disulfide

EINECS 200-282-7

1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-lysylglycinamide

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