Introduction：Basic information about CAS 522-70-3|Antimycin A3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Antimycin A3 |
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| CAS Number | 522-70-3 | Molecular Weight | 520.57200 |
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| Density | 1.25g/cm3 | Boiling Point | 745.5ºC at 760mmHg |
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| Molecular Formula | C26H36N2O9 | Melting Point | / |
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| MSDS | / | Flash Point | 404.7ºC |
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Names
| Name | Butanoic acid, 2(or3)-methyl-,(2R,3S,6S,7R,8R)-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-butyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylester |
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| Synonym | More Synonyms |
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Antimycin A3 BiologicalActivity
| Description | Antimycin A3, an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase. Antimycin A3 inhibits ATP-citrate lyase with a Ki value of 60.1 µM[1][2][3]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Infection |
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| In Vitro | Antimycin A3 induces apoptosis of cancer cells by selectively killing cancer cells that expressed high levels of anti-apoptotic Bcl-2 and Bcl-XL[1]. |
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| References | [1]. Ade Arsianti, et al. Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3. Tetrahedron.Volume 68, Issue 13, 1 April 2012, Pages 2884-2891. [2]. Miyoshi H, et al. Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3. [3]. Barrow CJ, et al. Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):729-33. |
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Chemical & Physical Properties
| Density | 1.25g/cm3 |
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| Boiling Point | 745.5ºC at 760mmHg |
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| Molecular Formula | C26H36N2O9 |
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| Molecular Weight | 520.57200 |
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| Flash Point | 404.7ºC |
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| Exact Mass | 520.24200 |
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| PSA | 157.33000 |
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| LogP | 3.80000 |
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| Index of Refraction | 1.549 |
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| InChIKey | PVEVXUMVNWSNIG-PDPGNHKXSA-N |
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| SMILES | CCCCC1C(=O)OC(C)C(NC(=O)c2cccc(NC=O)c2O)C(=O)OC(C)C1OC(=O)CC(C)C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NY1502900
- CHEMICAL NAME :
- Isovaleric acid, N-ester with N-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxo nan-3-yl) -3-formamidosalicylamide, stereoisomer
- CAS REGISTRY NUMBER :
- 522-70-3
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C26-H36-N2-O9
- MOLECULAR WEIGHT :
- 520.64
- WISWESSER LINE NOTATION :
- T9OV EOVTJ CMVR BQ CMVH& D1 G4 HOV1Y1&1 I1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,145,1967
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Safety Information
| Risk Phrases | 23/24/25 |
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| RIDADR | UN 3172 |
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| WGK Germany | 2 |
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| RTECS | EB3140000 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| antimycina3 |
| ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer |
| Blastmycin |
