Introduction：Basic information about CAS 72103-53-8|Tuftsin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tuftsin |
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| CAS Number | 72103-53-8 | Molecular Weight | 620.70 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C25H48N8O10 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Tuftsin diacetate |
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| Synonym | More Synonyms |
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Tuftsin BiologicalActivity
| Description | Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyPeptides |
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| In Vitro | Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2]. |
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| References | [1]. Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40. [2]. Wu M, et al. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimentalautoimmune encephalomyelitis. PLoS One. 2012;7(4):e34933. |
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Chemical & Physical Properties
| Molecular Formula | C25H48N8O10 |
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| Molecular Weight | 620.70 |
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| PSA | 289.78000 |
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| LogP | 0.53410 |
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| InChIKey | VXMJJWSIOFCHAC-GYFKHDNESA-N |
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| SMILES | CC(=O)O.CC(O)C(N)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O |
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| Storage condition | 2-8℃ |
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Synonyms
| tuftsin acetate salt hydrate |
| MFCD00133887 |
| THR-LYS-PRO-ARG ACETATE SALT |
| H-THR-LYS-PRO-ARG-OH ACOH |
| tuftsin acetate |
| H-THR-LYS-PRO-ARG-OH ACETATE SALT |
| TUFTSIN ACETATE SALT |
| Tuftsin |
| Tuftsin (diacetate) |
