Introduction：Basic information about CAS 81624-55-7|NSC348884, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC348884 |
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| CAS Number | 81624-55-7 | Molecular Weight | 636.791 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 1001.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H40N10 | Melting Point | / |
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| MSDS | / | Flash Point | 559.6±34.3 °C |
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Names
| Name | N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine |
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| Synonym | More Synonyms |
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NSC348884 BiologicalActivity
| Description | NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1] |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| References | [1]. Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 1001.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H40N10 |
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| Molecular Weight | 636.791 |
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| Flash Point | 559.6±34.3 °C |
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| Exact Mass | 636.343750 |
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| PSA | 121.20000 |
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| LogP | 4.74 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.768 |
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| InChIKey | KZOLQEUQAFTQFM-UHFFFAOYSA-N |
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| SMILES | Cc1ccc2nc(CN(CCN(Cc3nc4ccc(C)cc4[nH]3)Cc3nc4ccc(C)cc4[nH]3)Cc3nc4ccc(C)cc4[nH]3)[nH]c2c1 |
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| Storage condition | 2-8°C |
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Synonyms
| N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine |
| 1,2-Ethanediamine, N,N,N,N-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]- |
| NSC348884 |
