Introduction：Basic information about CAS 104746-04-5|Eslicarbazepine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Eslicarbazepine |
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| CAS Number | 104746-04-5 | Molecular Weight | 254.284 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 431.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C15H14N2O2 | Melting Point | 188-190°C |
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| MSDS | / | Flash Point | 214.6±31.5 °C |
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Names
| Name | Eslicarbazepine |
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| Synonym | More Synonyms |
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Eslicarbazepine BiologicalActivity
| Description | Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Eslicarbazepine is an anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. Eslicarbazepine acetate is a prodrug for eslicarbazepine (S-licarbazepine), which is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel[1][2]. |
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| References | [1]. Finelli E, et al. Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):229-231. [2]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 431.3±55.0 °C at 760 mmHg |
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| Melting Point | 188-190°C |
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| Molecular Formula | C15H14N2O2 |
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| Molecular Weight | 254.284 |
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| Flash Point | 214.6±31.5 °C |
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| Exact Mass | 254.105530 |
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| PSA | 66.56000 |
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| LogP | 0.93 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.677 |
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| InChIKey | BMPDWHIDQYTSHX-AWEZNQCLSA-N |
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| SMILES | NC(=O)N1c2ccccc2CC(O)c2ccccc21 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (+)-Licarbazepine |
| (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| (S)-(+)-licarbazepine |
| 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, (10S)- |
| T C676 BN&T&J BVZ IQ &&S Form |
| MHD |
| (S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| Eslicarbazepine |
| 5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide |
| (10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide |
| S-licarbazepine |
| (S)-Licarbazepine |
| S5VXA428R4 |
