CAS 107489-37-2|Thymoctonan

Introduction:Basic information about CAS 107489-37-2|Thymoctonan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameThymoctonan
CAS Number107489-37-2Molecular Weight918.04500
Density1.285g/cm3Boiling Point1331.1ºC at 760mmHg
Molecular FormulaC43H67N9O13Melting Point/
MSDS/Flash Point758.8ºC

Names

Name(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[2-[[2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
SynonymMore Synonyms

Thymoctonan BiologicalActivity

DescriptionThymoctonan (THF-γ2) is the immunomodulatory octapeptide, thymic humoral factor γ2. Thymoctonan has the half-life less than 6 min at 37 °C in blood from human, rat and mouse[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In VitroThymoctonan 形成的主要片段在人和大鼠血液中为 Glu-Asp-Gly-Pro-Lys Phe-Leu (2-8)、Asp-Gly Pro-Lys-Phe-Leu (3-8) 和 Glu-Asp Gly-Pro-Rys (2-6),在小鼠血液中为 2-8 和 2-6[1]。
References

[1]. Martignoni M, et al. Degradation of thymic humoral factor γ2 in human, rat and mouse blood: An experimental and theoretical study. Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140467.  

Chemical & Physical Properties

Density1.285g/cm3
Boiling Point1331.1ºC at 760mmHg
Molecular FormulaC43H67N9O13
Molecular Weight918.04500
Flash Point758.8ºC
Exact Mass917.48600
PSA358.85000
LogP2.41680
Vapour Pressure0mmHg at 25°C
Index of Refraction1.564
InChIKeyNYJVPTKMDYSZDU-MRNVWEPHSA-N
SMILESCC(C)CC(N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)O

Synonyms

THF-gamma2
Thymoctonan
Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu
C43H67N9O13
thymic humoral factor gamma2
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