Introduction：Basic information about CAS 27511-99-5|Eterobarb, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Eterobarb |
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| CAS Number | 27511-99-5 | Molecular Weight | 320.34000 |
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| Density | 1.203g/cm3 | Boiling Point | 418.2ºC at 760mmHg |
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| Molecular Formula | C16H20N2O5 | Melting Point | 116-118ºC |
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| MSDS | / | Flash Point | 206.7ºC |
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Names
| Name | Eterobarbital |
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| Synonym | More Synonyms |
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Eterobarb BiologicalActivity
| Description | Eterobarb (EX 12-095), a barbiturate derivative, is an anticonvulsant agent[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Eterobarb (25 mg/kg, i.p.) increases the threshold for the clonic seizure in mice[1] Animal Model: Mice[1] Dosage: 25 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the threshold for the clonic seizure by 1.75.degree. |
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| References | [1]. R H Mattson, et al. Eterobarb therapy in epilepsy. Neurology. 1976 Nov;26(11):1014-7. [2]. R M Julien, et al. Effectiveness of N,N'-dimethoxymethylphenobarbital (eterobarbital) on febrile seizures. Proc West Pharmacol Soc. 1977;20:73-7. |
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Chemical & Physical Properties
| Density | 1.203g/cm3 |
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| Boiling Point | 418.2ºC at 760mmHg |
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| Melting Point | 116-118ºC |
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| Molecular Formula | C16H20N2O5 |
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| Molecular Weight | 320.34000 |
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| Flash Point | 206.7ºC |
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| Exact Mass | 320.13700 |
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| PSA | 76.15000 |
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| LogP | 1.20880 |
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| Vapour Pressure | 3.34E-07mmHg at 25°C |
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| Index of Refraction | 1.526 |
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| InChIKey | DACOQFZGGLCXMA-UHFFFAOYSA-N |
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| SMILES | CCC1(c2ccccc2)C(=O)N(COC)C(=O)N(COC)C1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CQ0560000
- CHEMICAL NAME :
- Barbituric acid, 1,3-bis(methoxymethyl)-5-ethyl-5-phenyl-
- CAS REGISTRY NUMBER :
- 27511-99-5
- BEILSTEIN REFERENCE NO. :
- 0570278
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C16-H20-N2-O5
- MOLECULAR WEIGHT :
- 320.38
- WISWESSER LINE NOTATION :
- T6VNVNV FHJ B1O1 D1O1 F2 FR
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,602,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 490 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4046894
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Safety Information
Customs
| HS Code | 2933540000 |
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| Summary | 2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
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Synonyms
| 5-ethyl-1,3-bis(methoxymethyl)-5-phenyl-1,3-diazinane-2,4,6-trione |
