CAS 108341-18-0|Norepinephrine Bitartrate

Introduction：Basic information about CAS 108341-18-0|Norepinephrine Bitartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Norepinephrine Bitartrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles2
7. Synonyms

Common Name	Norepinephrine Bitartrate
CAS Number	108341-18-0	Molecular Weight	337.28
Density	/	Boiling Point	442.6ºC at 760mmHg
Molecular Formula	C₁₂H₁₉NO₁₀	Melting Point	100-104ºC(lit.)
MSDS	ChineseUSA	Flash Point	221.5ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	l-noradrenaline bitartrate
Synonym	More Synonyms

Norepinephrine Bitartrate BiologicalActivity

Description	Norepinephrine bitartrate monohydrate is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cardiovascular Disease
Target	EC50: 5.37 μM (β1-selective adrenergic receptor)[1]
In Vitro	Norepinephrine(NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2].
Cell Assay	Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].
References	[1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60.

Chemical & Physical Properties

Boiling Point	442.6ºC at 760mmHg
Melting Point	100-104ºC(lit.)
Molecular Formula	C₁₂H₁₉NO₁₀
Molecular Weight	337.28
Flash Point	221.5ºC
PSA	201.77000
Vapour Pressure	1.3E-08mmHg at 25°C
Index of Refraction	-11 ° (C=5, H2O)
InChIKey	LNBCGLZYLJMGKP-CDHMMBEJSA-N
SMILES	NCC(O)c1ccc(O)c(O)c1.O.O=C(O)C(O)C(O)C(=O)O
Storage condition	Refrigerator
Water Solubility	H2O: soluble50mg/mL, clear

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H310 + H330
Precautionary Statements	Missing Phrase - N15.00950417-P260-P262-P280-P302 + P352 + P310-P304 + P340 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	22-26-36/37/39-45-36/37-28
RIDADR	UN 2811
WGK Germany	3
RTECS	DN6750000
Packaging Group	III
HS Code	2922210000

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles2

6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

Vet. Pathol. 41 , 68, (2010)

Salmonella enterica serovar Typhimurium is an animal and zoonotic pathogen of worldwide importance. In pigs, transport and social stress are associated with reactivation and spread of Salmonella Typhi...

Skin blood flow and local temperature independently modify sweat rate during passive heat stress in humans.

J. Appl. Physiol. 109 , 1301-6, (2010)

Sweat rate (SR) is reduced in locally cooled skin, which may result from decreased temperature and/or parallel reductions in skin blood flow. The purpose of this study was to test the hypotheses that ...

Synonyms

Norepinephrine Bitartrate

L-Arterenol Bitartrate Monohydrate

(2R,3R)-2,3-Dihydroxysuccinic acid - 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol (1:1)

MFCD00150449

4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1)

Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-benzenediol (1:1)

L-(-)-Norepinephrine (+)-bitartrate salt monohydrate

4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1)

L-Norepinephrine Bitartrate Monohydrate

Noradrenaline bitartrate monohydrate

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt)

L-Norepinephrine Hydrogen L-Tartrate Monohydrate

4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1)

L-Noradrenaline Bitartrate Monohydrate

Norepinephrine (bitartrate monohydrate)

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