CAS 1118-90-7|α-Aminoadipic acid

Introduction：Basic information about CAS 1118-90-7|α-Aminoadipic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α-Aminoadipic acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles8
7. Synonyms

Common Name	α-Aminoadipic acid
CAS Number	1118-90-7	Molecular Weight	161.16
Density	1.3±0.1 g/cm3	Boiling Point	364.0±32.0 °C at 760 mmHg
Molecular Formula	C₆H₁₁NO₄	Melting Point	203-205ºC (dec.)
MSDS	ChineseUSA	Flash Point	173.9±25.1 °C

Names

Name	L-2-aminoadipic acid
Synonym	More Synonyms

α-Aminoadipic acid BiologicalActivity

Description	(S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >>Others
In Vitro	Ki值209 μML-α-Aminoadipic Acid是一种谷氨酰胺合成酶抑制剂。谷氨酰胺合成酶是一种酶，通过催化谷氨酸和氨缩合形成谷氨酰胺，在氮代谢中发挥重要作用。体外：先前的研究发现 DL-和 L-α-氨基己二酸 (alpha-AA) 具有特异性体外胶霉毒素。在 D-或 L-α-AA 存在下进行的与 D-或 L-α-AA 和 DL-[14C]-α-AA 放射自显影图一起孵育的培养物的 HPLC 分析表明星形神经胶质细胞 L-α-AA 摄取的立体特异性。星形胶质细胞对 alpha-AA 的摄取和 alpha-AA 诱导的胶质细胞毒性都是钠依赖性的。另一项研究发现，α-氨基己二酸的 L-异构体能够竞争性抑制转运蛋白，而α-氨基己二酸的 D-异构体则无效。此外，发现 L-α 氨基己二酸是谷氨酰胺合成酶和 γ-谷氨酰半胱氨酸合成酶的竞争性抑制剂。相反，α-氨基己二酸的 D-异构体对这两种酶的抑制作用要弱得多。体内：动物研究表明，La-氨基己二酸可以剂量依赖性降低海马体中内源性细胞外犬尿酸的水平endent fashion ），尽管 La-氨基己二酸的作用似乎不如它减少从头产生的犬尿酸。临床试验：迄今为止，尚未进行临床研究。参考文献： Huck, S., Grass, F. 和 Hrtnagl, H. 谷氨酸类似物 α-氨基己二酸在体外发挥其神经毒性作用之前被星形胶质细胞吸收。神经科学杂志 4(10), 2650-2657 (1984).麦克比恩 GJ。胶霉毒素α-氨基己二酸对大鼠纹状体中谷氨酸转运蛋白和神经胶质酶的抑制作用。Br J 药效学。1994 年 10 月；113(2):536-40. Wu HQ, Ungerstedt U, Schwarcz R. L-α-氨基己二酸作为海马体中犬尿酸生成的调节剂：自由活动大鼠的微透析研究。欧洲药理学杂志。1995 年 7 月 25 日；281(1)：55-61。

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	364.0±32.0 °C at 760 mmHg
Melting Point	203-205ºC (dec.)
Molecular Formula	C₆H₁₁NO₄
Molecular Weight	161.16
Flash Point	173.9±25.1 °C
Exact Mass	161.068802
PSA	100.62000
LogP	-0.54
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.515
InChIKey	OYIFNHCXNCRBQI-BYPYZUCNSA-N
SMILES	NC(CCCC(=O)O)C(=O)O

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922499990

Customs

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles8

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Orally Administered Mucolytic Drug l-Carbocisteine Inhibits Angiogenesis and Tumor Growth in Mice.

J. Pharmacol. Exp. Ther. 354 , 269-78, (2015)

Angiogenesis, the formation of new blood vessels from pre-existing vessels, is essential for the growth and metastasis of tumors. In this study, we found that l-carbocisteine, a widely used expectoran...

Synonyms

L-2-Aminoadipic acid

2-Aminohexanedioic acid

2-aminoadipic acid

AAD

MFCD00002636

a-Aminoadipate

DL-2-Aminohexanedioic acid

(S)-2-Aminohexanedioic acid,L-Homoglutamic acid,Aad

Hexanedioic acid, 2-amino-, (2S)-

Hexanedioic acid, 2-amino-

α-Amino-adipic acid

UNII:1K7B1OED4N

L-a-Aminoadipic acid

DL-a-aminoadipic acid

(S)-2-Aminohexanedioic acid

a-Aminoadipic acid

(2S)-2-Aminohexanedioic acid

(±)-2-Aminoadipic acid

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