CAS 4604-41-5|3,3'-diiodo-L-thyronine
| Common Name | 3,3'-diiodo-L-thyronine | ||
|---|---|---|---|
| CAS Number | 4604-41-5 | Molecular Weight | 525.077 |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 520.7±50.0 °C at 760 mmHg |
| Molecular Formula | C15H13I2NO4 | Melting Point | 178-180ºC |
| MSDS | USA | Flash Point | 268.7±30.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3,3'-diiodo-L-thyronine |
|---|---|
| Synonym | More Synonyms |
3,3'-diiodo-L-thyronine BiologicalActivity
| Description | 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>COXResearch Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite COX |
| In Vitro | 3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity[2]. 3,3'-Diiodo-L-thyronine of 1 μM has the maximum effect[2]. 3,3'-Diiodo-L-thyronine is produced by further degradation of T3 and rT3[3]. |
| References | [1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88. [2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94. [3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185. |
Chemical & Physical Properties
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 520.7±50.0 °C at 760 mmHg |
| Melting Point | 178-180ºC |
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.077 |
| Flash Point | 268.7±30.1 °C |
| Exact Mass | 524.893372 |
| PSA | 92.78000 |
| LogP | 4.55 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | CPCJBZABTUOGNM-LBPRGKRZSA-N |
| SMILES | NC(Cc1ccc(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
| Storage condition | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
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Synonyms
| 3,3’-Diiodo-L-thyronine |
| O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine |
| 3,3'-Diiodo-L-thyronine |
| L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo- |
| EINECS 225-005-7 |
