CAS 90566-53-3|Fluticasone

Introduction：Basic information about CAS 90566-53-3|Fluticasone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fluticasone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Fluticasone
CAS Number	90566-53-3	Molecular Weight	500.571
Density	1.3±0.1 g/cm3	Boiling Point	568.3±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₁F₃O₅S	Melting Point	-18.1ºC
MSDS	/	Flash Point	297.5±30.1 °C

Names

Name	fluticasone
Synonym	More Synonyms

Fluticasone BiologicalActivity

Description	Fluticasone is an inhaled corticosteroid used for respiratory diseases[1]. Fluticasone is a Smo agonist s with a IC50 value of 99 nM. Fluticasone activate Hedgehog signaling and promotes the proliferation of primary neuronal stem/precursor cells[2].
Related Catalog	Signaling Pathways >>Stem Cell/Wnt >>SmoResearch Areas >>EndocrinologyResearch Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor
In Vitro	Fluticasone (0-10 μM, 2 hours) inhibits the U2OS cells growth with the EC50 of 99 nM[2]. Fluticasone (10-1000 nM, 48 hours) decreases HRV-induced mucin production and involves modulation of SPDEF-regulated genes and extracellular ATP release[3].
In Vivo	Fluticasone (intranasal dropping; 1mg/kg; 7 days) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4]. Animal Model: C57BL/6 mice[4] Dosage: 1 mg/kg Administration: Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days Result: Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.
References	[1]. Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13(1):90. [2]. Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9323-8. [3]. Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun. [4]. Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385(Suppl 1):S88.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	568.3±50.0 °C at 760 mmHg
Melting Point	-18.1ºC
Molecular Formula	C₂₅H₃₁F₃O₅S
Molecular Weight	500.571
Flash Point	297.5±30.1 °C
Exact Mass	500.184418
PSA	105.97000
LogP	3.73
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.556
InChIKey	MGNNYOODZCAHBA-UHFFFAOYSA-N
SMILES	CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)SCF

Synonyms

Fluticasone propionate (JAN/USAN)

Flonase

Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(fluoromethyl) ester, (6α,11β,16α,17α)-

S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate

Flovent DPI

UNII-CUT2W21N7U

Flixonase

Flutionum

Flutiona [Spanish]

(6α,11β,16α,17α)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate

Flixotide

Fluticasone

Fluticasone propionate

Flutiona

flutione

Fluticaps (TN)

(6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate

(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid S-(Fluoromethyl) Ester

flovent diskus

Flutionum [Latin]

Flutione (INN)

Cutivate

MFCD01862254

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