Introduction：Basic information about CAS 905854-03-7|(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Py, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione |
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| CAS Number | 905854-03-7 | Molecular Weight | 369.41600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H19N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3S,4S) |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | (3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Remsing Rix LL, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9(2):353-8. |
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Chemical & Physical Properties
| Molecular Formula | C23H19N3O2 |
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| Molecular Weight | 369.41600 |
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| Exact Mass | 369.14800 |
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| PSA | 66.89000 |
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| LogP | 3.92140 |
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| InChIKey | UCEQXRCJXIVODC-WOJBJXKFSA-N |
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| SMILES | O=C1NC(=O)C(c2cn3c4c(cccc24)CCC3)C1c1c[nH]c2ccccc12 |
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| Storage condition | 2-8°C |
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Synonyms
| (+-)-trans-2-Propylamino-cyclohexanol-(1) |
| (+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione |
| 2-(propylamino)cyclohexanol |
| (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione |
| (1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL |
