Introduction：Basic information about CAS 35286-59-0|Ziyuglycoside II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ziyuglycoside II |
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| CAS Number | 35286-59-0 | Molecular Weight | 604.814 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 716.2±60.0 °C at 760 mmHg |
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| Molecular Formula | C35H56O8 | Melting Point | 260-263℃ |
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| MSDS | / | Flash Point | 218.6±26.4 °C |
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Names
| Name | (3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid |
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| Synonym | More Synonyms |
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Ziyuglycoside II BiologicalActivity
| Description | Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSResearch Areas >>Inflammation/Immunology |
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| In Vitro | Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively[1]. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h[1]. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells[1]. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent[1]. Cell Viability Assay[1] Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μM Incubation Time: 24 hours and 48 hours Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: The apoptotic rate was significantly increased in comparison to that of the control. Western Blot Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Treatment resulted in increased expressions of both p53 and p21. |
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| References | [1]. Zhu X, et al. Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway. Int J Mol Sci. 2013 Sep 3;14(9):18041-55. [2]. Zhu X, et al. Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicol Lett. 2014 May 16;227(1):65-73. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 716.2±60.0 °C at 760 mmHg |
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| Melting Point | 260-263℃ |
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| Molecular Formula | C35H56O8 |
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| Molecular Weight | 604.814 |
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| Flash Point | 218.6±26.4 °C |
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| Exact Mass | 604.397522 |
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| PSA | 136.68000 |
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| LogP | 7.68 |
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| Vapour Pressure | 0.0±5.2 mmHg at 25°C |
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| Index of Refraction | 1.588 |
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| InChIKey | MFIXLWYJTVEVGO-YHGWSDCJSA-N |
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| SMILES | CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1(C)O |
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| Storage condition | 2-8°C |
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Synonyms
| Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)- |
| zirconyl carbonate |
| (3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid |
| Ziyuglycoside II |
| Zirconium carbonate oxide |
