CAS 883050-24-6|CCG 50014

Introduction：Basic information about CAS 883050-24-6|CCG 50014, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CCG 50014 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	CCG 50014
CAS Number	883050-24-6	Molecular Weight	316.35000
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₁₃FN₂O₂S	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Synonym	More Synonyms

CCG 50014 BiologicalActivity

Description	CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>RGS Protein
Target	RGS4:30 nM (IC50) RGS8:11 μM (IC50) RGS16:3.5 μM (IC50) RGS19:0.12 μM (IC50)
In Vivo	CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2].
References	[1]. Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92. [2]. Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7.

Chemical & Physical Properties

Molecular Formula	C₁₆H₁₃FN₂O₂S
Molecular Weight	316.35000
Exact Mass	316.06800
PSA	72.24000
LogP	2.55650
InChIKey	QUIIIYITNGOFEI-UHFFFAOYSA-N
SMILES	Cc1ccc(-n2sc(=O)n(Cc3ccc(F)cc3)c2=O)cc1
Storage condition	-20℃

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

2-p-tolyl-4-(4-fluorobenzyl)-1,2,4-thiadiazolidine-3,5-dione

UNII-RA72G28VE9

4-((4-fluorophenyl)methyl)-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

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