CAS 897732-93-3|JNJ-38431055

Introduction：Basic information about CAS 897732-93-3|JNJ-38431055, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. JNJ-38431055 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	JNJ-38431055
CAS Number	897732-93-3	Molecular Weight	479.550
Density	1.3±0.1 g/cm3	Boiling Point	648.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₉N₅O₆S	Melting Point	/
MSDS	/	Flash Point	345.9±31.5 °C

Names

Name	propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate
Synonym	More Synonyms

JNJ-38431055 BiologicalActivity

Description	APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.IC50 value: 46 nM (EC50) [1]Target: hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1]
Related Catalog	Signaling Pathways >>GPCR/G Protein >>GPR119Research Areas >>Metabolic Disease
References	[1]. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335. [2]. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755. [3]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351.

Description

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.IC50 value: 46 nM (EC50) [1]Target: hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1]

Related Catalog

Signaling Pathways >>GPCR/G Protein >>GPR119Research Areas >>Metabolic Disease

References

[1]. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335.

[2]. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755.

[3]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	648.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₉N₅O₆S
Molecular Weight	479.550
Flash Point	345.9±31.5 °C
Exact Mass	479.183868
PSA	141.22000
LogP	2.90
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.570
InChIKey	WPDCHTSXOPUOII-UHFFFAOYSA-N
SMILES	COc1c(Nc2ccc(S(C)(=O)=O)nc2C)ncnc1OC1CCN(C(=O)OC(C)C)CC1
Storage condition	-20℃

Synonyms

adp-597

Isopropyl 4-[(5-methoxy-6-{[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino}-4-pyrimidinyl)oxy]-1-piperidinecarboxylate

1-Piperidinecarboxylic acid, 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-, 1-methylethyl ester

JNJ-38431055

APD597

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