Introduction：Basic information about CAS 327056-22-4|VU 0285683, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | VU 0285683 |
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| CAS Number | 327056-22-4 | Molecular Weight | 266.23000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C14H7FN4O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
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VU 0285683 BiologicalActivity
| Description | VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| References | [1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. |
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Chemical & Physical Properties
| Molecular Formula | C14H7FN4O |
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| Molecular Weight | 266.23000 |
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| Exact Mass | 266.06000 |
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| PSA | 75.60000 |
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| LogP | 2.80938 |
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| InChIKey | GELAFISMURFRCA-UHFFFAOYSA-N |
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| SMILES | N#Cc1cc(F)cc(-c2nc(-c3ccccn3)no2)c1 |
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