CAS 487-39-8|Phillygenin

Introduction：Basic information about CAS 487-39-8|Phillygenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Phillygenin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Phillygenin
CAS Number	487-39-8	Molecular Weight	372.412
Density	1.2±0.1 g/cm3	Boiling Point	534.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₆	Melting Point	133ºC
MSDS	/	Flash Point	277.3±30.1 °C

Names

Name	4-[(3S,3aR,6R,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
Synonym	More Synonyms

Phillygenin BiologicalActivity

Description	Phillygenin is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.In vitro : 1) Phillygenin shows a greater inhibition on mouse B16 melanoma cells potential than vincristine.2) phillygenin had notable scavenging activity against DPPH, ABTS radicals, as well as potent reducing power in FRAP assay.In vivo: The reference for rat is 5.6 mg/m l ( i.v).
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Phenylpropanoids
References	[1]. Ye LH et al. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Eur J Drug Metab Pharmacokinet, 2013 Sep, 38(3):201-7. [2]. Song W et al. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc, 2012 Jan, 85(1):120-6.

Description

Phillygenin is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.In vitro : 1) Phillygenin shows a greater inhibition on mouse B16 melanoma cells potential than vincristine.2) phillygenin had notable scavenging activity against DPPH, ABTS radicals, as well as potent reducing power in FRAP assay.In vivo: The reference for rat is 5.6 mg/m l ( i.v).

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Phenylpropanoids

References

[1]. Ye LH et al. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Eur J Drug Metab Pharmacokinet, 2013 Sep, 38(3):201-7.

[2]. Song W et al. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc, 2012 Jan, 85(1):120-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	534.9±50.0 °C at 760 mmHg
Melting Point	133ºC
Molecular Formula	C₂₁H₂₄O₆
Molecular Weight	372.412
Flash Point	277.3±30.1 °C
Exact Mass	372.157288
PSA	66.38000
LogP	2.31
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.570
InChIKey	CPJKKWDCUOOTEW-YJPXFSGGSA-N
SMILES	COc1cc(C2OCC3C(c4ccc(OC)c(OC)c4)OCC23)ccc1O

Synonyms

philligenin

sylvatesmin

Phillygenol

4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenol

(+)-Phillygenin

Epipinoresinol methyl ether

Phenol, 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-

phylligenin

Phillygenin

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