Introduction：Basic information about CAS 19350-66-4|AV-153 free base, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AV-153 free base |
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| CAS Number | 19350-66-4 | Molecular Weight | 297.30400 |
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| Density | 1.23g/cm3 | Boiling Point | 450.5ºC at 760mmHg |
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| Molecular Formula | C14H19NO6 | Melting Point | / |
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| MSDS | / | Flash Point | 226.3ºC |
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Names
| Name | 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid |
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| Synonym | More Synonyms |
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AV-153 free base BiologicalActivity
| Description | AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| In Vitro | AV-153 free base causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively[1]. AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%[1]. |
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| References | [1]. Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587(1-2):52-8. [2]. E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7. [3]. Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123. |
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Chemical & Physical Properties
| Density | 1.23g/cm3 |
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| Boiling Point | 450.5ºC at 760mmHg |
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| Molecular Formula | C14H19NO6 |
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| Molecular Weight | 297.30400 |
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| Flash Point | 226.3ºC |
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| Exact Mass | 297.12100 |
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| PSA | 101.93000 |
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| LogP | 1.29340 |
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| Vapour Pressure | 2.26E-09mmHg at 25°C |
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| Index of Refraction | 1.51 |
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| InChIKey | USGQSNVLGQWBEC-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C(=O)O |
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester |
| 2.6-dimethyl-3,5-diethoxycarbonyl-1-4-dihydroisonicotinic acid |
| 3,5-Diethoxycarbonyl-2,6-dimethyl-1,4-dihydroisonicotinsaeure |
| 2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydro-pyridin-4-carbonsaeure |
| 3,4,5-pyridinetricarboxylic acid,1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester |
| 2,5-DIISOPROPYLPHENOL |
