CAS 1431985-92-0|K 02288
Introduction：Basic information about CAS 1431985-92-0|K 02288, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | K 02288 | ||
|---|---|---|---|
| CAS Number | 1431985-92-0 | Molecular Weight | 352.384 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 522.2±50.0 °C at 760 mmHg |
| Molecular Formula | C20H20N2O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 269.6±30.1 °C |
| Symbol | GHS05, GHS06 | Signal Word | Danger |
Names
| Name | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol |
|---|---|
| Synonym | More Synonyms |
K 02288 BiologicalActivity
| Description | K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ALKSignaling Pathways >>TGF-beta/Smad >>TGF-β ReceptorResearch Areas >>Others |
| Target | IC50：1.8 nM (ALK1), 1.1 nM (ALK2), 34.4 nM (ALK3), 6.3 nM (ALK6), 302 nM (ALK4), 321 nM (ALK5)[1] |
| In Vitro | K02288 reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 causes near complete inhibition of Smad2 phosphorylation at 0.5 µM[1]. K02288 binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2]. |
| In Vivo | K02288 (1 µM) induces dysfunctional angiogenesis in a chick embryo CAM model[2]. |
| References | [1]. Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721. [2]. Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 522.2±50.0 °C at 760 mmHg |
| Molecular Formula | C20H20N2O4 |
| Molecular Weight | 352.384 |
| Flash Point | 269.6±30.1 °C |
| Exact Mass | 352.142303 |
| PSA | 86.83000 |
| LogP | 3.13 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | CJLMANFTWLNAKC-UHFFFAOYSA-N |
| SMILES | COc1cc(-c2cc(-c3cccc(O)c3)cnc2N)cc(OC)c1OC |
Safety Information
| Symbol | GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H318 |
| Precautionary Statements | P280-P301 + P310 + P330-P305 + P351 + P338 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
Synonyms
| 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol |
| Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]- |
| K02288 |
