CAS 272786-64-8|2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

Introduction：Basic information about CAS 272786-64-8|2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
CAS Number	272786-64-8	Molecular Weight	298.33
Density	1.5±0.1 g/cm3	Boiling Point	479.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₅FN₂O₃S	Melting Point	/
MSDS	/	Flash Point	243.8±31.5 °C

Names

Name	2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
Synonym	More Synonyms

BiologicalActivity

Description	Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research[1][2].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
References	[1]. Elisabetta Martini, et al. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. Bioorg Med Chem. 2008 Dec 1;16(23):10034-42. [2]. N Galeotti, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol

Description

Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research[1][2].

Related Catalog

Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR

References

[1]. Elisabetta Martini, et al. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. Bioorg Med Chem. 2008 Dec 1;16(23):10034-42.

[2]. N Galeotti, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	479.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₅FN₂O₃S
Molecular Weight	298.33
Flash Point	243.8±31.5 °C
Exact Mass	298.078735
PSA	66.07000
LogP	0.66
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.628
InChIKey	SNRTZFZAFBIBJP-UHFFFAOYSA-N
SMILES	O=C1CCC2CN(S(=O)(=O)c3ccc(F)cc3)CCN12

Synonyms

Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro-

Unifiram

UNII:N4024LN29G

2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

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