CAS 1092484-56-4|Fenofibrate-d6

Introduction：Basic information about CAS 1092484-56-4|Fenofibrate-d6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fenofibrate-d6 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Fenofibrate-d6
CAS Number	1092484-56-4	Molecular Weight	366.868
Density	1.2±0.1 g/cm3	Boiling Point	469.8±35.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₅ClD₆O₄	Melting Point	/
MSDS	/	Flash Point	165.4±24.9 °C

Names

Name	propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-3,3,3-trideuterio-2-(trideuteriomethyl)propanoate
Synonym	More Synonyms

Fenofibrate-d6 BiologicalActivity

Description	Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
Related Catalog	Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Cell Cycle/DNA Damage >>PPAR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schelleman H, et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48. [3]. Gong Y, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964(16)30448-0.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	469.8±35.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₅ClD₆O₄
Molecular Weight	366.868
Flash Point	165.4±24.9 °C
Exact Mass	366.150482
PSA	52.60000
LogP	4.80
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.547
InChIKey	YMTINGFKWWXKFG-LIJFRPJRSA-N
SMILES	CC(C)OC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1

Synonyms

Lipirex-d6

Nolipax-d6

Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-(H)methyl(H)propanoate

Lipofene-d6

Lipsin-d6

Lipantil-d6

Lipanthyl-d6

Propanoic-3,3,3-d acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-(methyl-d)-, 1-methylethyl ester

Fenofibrate-d6

Liposit-d6

MeltDose-d6

Lipoclar-d6

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