CAS 1093070-14-4|PLpro inhibitor

Introduction：Basic information about CAS 1093070-14-4|PLpro inhibitor, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. PLpro inhibitor BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	PLpro inhibitor
CAS Number	1093070-14-4	Molecular Weight	346.42200
Density	/	Boiling Point	/
Molecular Formula	C₂₂H₂₂N₂O₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	5-acetamido-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
Synonym	More Synonyms

PLpro inhibitor BiologicalActivity

Description	PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo:
Related Catalog	Signaling Pathways >>Anti-infection >>SARS-CoVResearch Areas >>Infection
References	[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24. [2]. http://www.google.com/patents/WO2010022355A1cl=en

Description

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.IC50 Value: 2.6 uM [1]Target: PLpro; SARS-CoVin vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].in vivo:

Related Catalog

Signaling Pathways >>Anti-infection >>SARS-CoVResearch Areas >>Infection

References

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.

[2]. http://www.google.com/patents/WO2010022355A1cl=en

Chemical & Physical Properties

Molecular Formula	C₂₂H₂₂N₂O₂
Molecular Weight	346.42200
Exact Mass	346.16800
PSA	65.18000
LogP	5.30340
Storage condition	2-8℃

Synonyms

5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide

PLpro inhibitor

5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

I06-1404

5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

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