CAS 566-48-3|Formestane
Introduction：Basic information about CAS 566-48-3|Formestane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Formestane | ||
|---|---|---|---|
| CAS Number | 566-48-3 | Molecular Weight | 302.408 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 475.4±45.0 °C at 760 mmHg |
| Molecular Formula | C19H26O3 | Melting Point | 199-202°C |
| MSDS | ChineseUSA | Flash Point | 255.4±25.2 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | formestane |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 475.4±45.0 °C at 760 mmHg |
| Melting Point | 199-202°C |
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.408 |
| Flash Point | 255.4±25.2 °C |
| Exact Mass | 302.188202 |
| PSA | 54.37000 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.570 |
| InChIKey | OSVMTWJCGUFAOD-KZQROQTASA-N |
| SMILES | CC12CCC3C(CCC4=C(O)C(=O)CCC43C)C1CCC2=O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 182 mg/kg
- SEX/DURATION :
- female 3-5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
- REFERENCE :
- JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 118,93,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 136 mg/kg
- SEX/DURATION :
- female 2-4 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 118,93,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 11-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 36,29,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- female 3-7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 100,1684,1977
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R60 |
| Safety Phrases | S53-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | BV8152500 |
Articles36
More Articles| Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos. PLoS ONE 7 , e36069, (2012) The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is... | |
| Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells. Cancer Sci. 101 , 1661-9, (2010) In breast cancer, stromal cells surrounding cancer epithelial cells can influence phenotype by producing paracrine factors. Among many mediators of epithelial-stromal interactions, aromatase activity ... | |
| The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio). Curr. Eye Res. 32(10) , 819-27, (2007) It has been shown that the steroid hormone estrogen plays an important role in the development of the central nervous system. The purpose of these studies was to determine the effect of estrogen on ze... |
Synonyms
| Androst-4-ene-3,17-dione, 4-hydroxy- |
| 4-Hydroxyandrost-4-ene-3,17-dione |
| 4-Hydroxy-4-androstene-3,17-dione |
| Formestane |
| B,Aromatase inhibitor |
| Lentaron |
| 4-androsten-4-ol-3,17-dione |
| 4-Hydroxyandrostenedione |
| 4-OH-A |
| MFCD00057814 |
| (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione |
