Introduction：Basic information about CAS 1005334-57-5|CVT 10216, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CVT 10216 |
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| CAS Number | 1005334-57-5 | Molecular Weight | 465.475 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 714.2±70.0 °C at 760 mmHg |
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| Molecular Formula | C24H19NO7S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 385.8±35.7 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid |
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| Synonym | More Synonyms |
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CVT 10216 BiologicalActivity
| Description | CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Aldehyde Dehydrogenase (ALDH)Research Areas >>Neurological Disease |
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| Target | IC50: 29 nM (ALDH-2)[1] |
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| In Vivo | CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1]. CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1]. |
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| References | [1]. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 714.2±70.0 °C at 760 mmHg |
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| Molecular Formula | C24H19NO7S |
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| Molecular Weight | 465.475 |
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| Flash Point | 385.8±35.7 °C |
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| Exact Mass | 465.088226 |
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| PSA | 131.29000 |
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| LogP | 3.55 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.676 |
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| InChIKey | YYOOFJZTRCPVFD-UHFFFAOYSA-N |
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| SMILES | CS(=O)(=O)Nc1ccc(-c2coc3cc(OCc4cccc(C(=O)O)c4)ccc3c2=O)cc1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| Benzoic acid, 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]- |
| 3-{[(3-{4-[(Methylsulfonyl)amino]phenyl}-4-oxo-4H-chromen-7-yl)oxy]methyl}benzoic acid |
| CVT-10216 |
