Introduction：Basic information about CAS 108340-60-9|ganoderic acid D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ganoderic acid D |
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| CAS Number | 108340-60-9 | Molecular Weight | 514.650 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 688.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H42O7 | Melting Point | / |
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| MSDS | / | Flash Point | 384.1±28.0 °C |
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Names
| Name | ganoderic acid D |
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| Synonym | More Synonyms |
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ganoderic acid D BiologicalActivity
| Description | Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>SirtuinResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Sirtuin |
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| Target | SIRT3 |
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| References | [1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77. [2]. Yue QX，et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 688.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H42O7 |
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| Molecular Weight | 514.650 |
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| Flash Point | 384.1±28.0 °C |
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| Exact Mass | 514.293030 |
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| PSA | 125.81000 |
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| LogP | 2.43 |
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| Vapour Pressure | 0.0±4.9 mmHg at 25°C |
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| Index of Refraction | 1.559 |
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| InChIKey | YTVGSCZIHGRVAV-UHFFFAOYSA-N |
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| SMILES | CC(CC(=O)CC(C)C1CC(=O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O)C(=O)O |
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Synonyms
| Ganoderic-acid-D |
| Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)- |
| GanodericacidD |
| (7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid |
