Introduction：Basic information about CAS 661-19-8|1-Docosanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
Related Catalog
Signaling Pathways >>Anti-infection >>HSVResearch Areas >>Infection
References
[1]. Katz DH, et al. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10825-9.
[2]. Sacks SL, et al. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial. J Am Acad Dermatol. 2001 Aug;45(2):222-30.
Chemical & Physical Properties
Density
0.8±0.1 g/cm3
Boiling Point
375.9±5.0 °C at 760 mmHg
Melting Point
65-72 °C(lit.)
Molecular Formula
C22H46O
Molecular Weight
326.600
Flash Point
142.5±5.2 °C
Exact Mass
326.354858
PSA
20.23000
LogP
10.44
Vapour Pressure
0.0±1.9 mmHg at 25°C
Index of Refraction
1.455
InChIKey
NOPFSRXAKWQILS-UHFFFAOYSA-N
SMILES
CCCCCCCCCCCCCCCCCCCCCCO
Storage condition
2-8°C
Stability
Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility
Insoluble
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
JR1315000
CHEMICAL NAME :
1-Docosanol
CAS REGISTRY NUMBER :
661-19-8
BEILSTEIN REFERENCE NO. :
1770470
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C22-H46-O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2018 No. of Facilities: 151 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1358 (estimated)
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