Introduction：Basic information about CAS 6681-15-8|Jatrorrhizine Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Jatrorrhizine Hydrochloride |
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| CAS Number | 6681-15-8 | Molecular Weight | 374.83800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H20ClNO4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | jatrorrhizine hcl(rg) |
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| Synonym | More Synonyms |
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Jatrorrhizine Hydrochloride BiologicalActivity
| Description | Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | Uptake-2 transporter[1] |
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| In Vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1]. Jatrorrhizine chloride significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1]. Jatrorrhizine chloride demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1]. Jatrorrhizine chloride attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2]. |
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| References | [1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243. |
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Chemical & Physical Properties
| Molecular Formula | C20H20ClNO4 |
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| Molecular Weight | 374.83800 |
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| Exact Mass | 374.11600 |
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| PSA | 51.80000 |
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| LogP | 3.88380 |
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| InChIKey | JKMUUZMCSNHBAX-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(cc1O)CC[n+]1cc3c(OC)c(OC)ccc3cc1-2.[Cl-] |
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Synonyms
| Jatorrhizine,chloride |
| 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydro-isochino[3,2-a]isochinolinylium,Chlorid |
| Jatrorrhizine chloride |
| 3-hydroxy-2,9,10-trimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium,chloride |
| JatrorrhizineHydrochloride |
| Neprotine chloride |
| Jatrochizine chloride |
| Jatrorrhizine Hydrochloride |
