CAS 1772-03-8|D-(+)-Galactosamine hydrochloride

Introduction：Basic information about CAS 1772-03-8|D-(+)-Galactosamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. D-(+)-Galactosamine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	D-(+)-Galactosamine hydrochloride
CAS Number	1772-03-8	Molecular Weight	215.63
Density	/	Boiling Point	532.5ºC at 760 mmHg
Molecular Formula	C₆H₁₄ClNO₅	Melting Point	182-185 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	275.8ºC

Names

Name	D(+)-Galactosamine hydrochloride
Synonym	More Synonyms

D-(+)-Galactosamine hydrochloride BiologicalActivity

Description	D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure[1][2].
Related Catalog	Research Areas >>Inflammation/Immunology
References	[1]. Ayhanci A, et al. Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats. Cytotechnology. 2016;68(5):1763-1770. [2]. Okumura A, et al. Alleviation of lipopolysaccharide/d-galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice. Biochem Biophys Rep. 2017;12:166-171. Published 2017 Oct 13.

Description

D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure[1][2].

Related Catalog

Research Areas >>Inflammation/Immunology

References

[1]. Ayhanci A, et al. Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats. Cytotechnology. 2016;68(5):1763-1770.

[2]. Okumura A, et al. Alleviation of lipopolysaccharide/d-galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice. Biochem Biophys Rep. 2017;12:166-171. Published 2017 Oct 13.

Chemical & Physical Properties

Boiling Point	532.5ºC at 760 mmHg
Melting Point	182-185 °C (dec.)(lit.)
Molecular Formula	C₆H₁₄ClNO₅
Molecular Weight	215.63
Flash Point	275.8ºC
Exact Mass	215.056046
PSA	116.17000
Vapour Pressure	5.53E-10mmHg at 25°C
Index of Refraction	96 ° (C=1, H2O)
InChIKey	QKPLRMLTKYXDST-BMZZJELJSA-N
SMILES	Cl.NC1C(O)OC(CO)C(O)C1O
Storage condition	2~8°C
Water Solubility	SOLUBLE

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LW5500000
HS Code	2922399090

Customs

HS Code	2922399090
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles3

An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.

Genes Immun. 15(5) , 320-32, (2014)

Genetic and immunological analysis of host-pathogen interactions can reveal fundamental mechanisms of susceptibility and resistance to infection. Modeling human infectious diseases among inbred mouse ...

Towards a full integration of optimization and validation phases: An analytical-quality-by-design approach

J. Chromatogr. A. 1395 , 88-98, (2015)

• An enhanced quality-by-design strategy throughout the analytical method lifecycle. • Quantitative design space: an innovative approach for development of analytical methods. • Integrated approaches ...

Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.

Leukemia 29(1) , 145-56, (2015)

The systemic inflammatory response observed during acute graft-versus-host disease (aGVHD) is driven by proinflammatory cytokines, a 'cytokine storm'. The function of plasmin in regulating the inflamm...

Synonyms

Galactosamine

2-Amino-2-deoxy-D-galactopyranose hydrochloride D-Chondrosamine hydrochloride

D-GalactosaMine HC1

2-deoxy-2-amino-D-galactose hydrochloride

α-D-Galactopyranose, 2-amino-2-deoxy-, hydrochloride (1:1)

GALACTOSAMINE HCL

2-aMino-2-deoxy-L-idose

D-GALN HCL

D-(+)-Galactosamine hydrochloride

2-Amino-2-deoxy-D-galactopyranose hydrochloride,D-Chondrosamine hydrochloride

2-amino-2-deoxy-D-galactopyranose hydrochloride

Chondrosamine Hydrochloride

2-Amino-2-deoxy-α-D-galactopyranose hydrochloride (1:1)

D-GALACTOSAMINE HCL

CHONDROSAMINE

EINECS 217-198-1

MFCD00135830

(2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride

D-CHONDROSAMINE HCL

GALACTOSAMINE HCL,D

N-Acetylgalactosamine hydrochloride

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