CAS 60-19-5|Tyramine
Introduction：Basic information about CAS 60-19-5|Tyramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyramine | ||
|---|---|---|---|
| CAS Number | 60-19-5 | Molecular Weight | 137.179 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 325.2±0.0 °C at 760 mmHg |
| Molecular Formula | C8H12ClNO | Melting Point | 253-255 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 119.2±20.4 °C |
Names
| Name | Tyramine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Tyramine BiologicalActivity
| Description | Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | Tyramine is normally broken down in your body by an enzyme called MAO (monoamine oxidase)[1]. |
| References | [1]. C Brown , et al. The Monoamine Oxidase Inhibitor-Tyramine Interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 325.2±0.0 °C at 760 mmHg |
| Melting Point | 253-255 °C(lit.) |
| Molecular Formula | C8H12ClNO |
| Molecular Weight | 137.179 |
| Flash Point | 119.2±20.4 °C |
| Exact Mass | 137.084061 |
| PSA | 46.25000 |
| LogP | 0.72 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.577 |
| InChIKey | RNISDHSYKZAWOK-UHFFFAOYSA-N |
| SMILES | Cl.NCCc1ccc(O)cc1 |
| Storage condition | Store at RT. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 208 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1044 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 2530 umol/L
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 2530 umol/L
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25-S36-S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NL4375000 |
| HS Code | 29222900 |
Customs
| HS Code | 2922299090 |
|---|---|
| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles15
More Articles| Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... | |
| New procedure of selected biogenic amines determination in wine samples by HPLC. Anal. Chim. Acta 834 , 58-66, (2014) A new procedure for determination of biogenic amines (BA): histamine, phenethylamine, tyramine and tryptamine, based on the derivatization reaction with 2-chloro-1,3-dinitro-5-(trifluoromethyl)-benzen... | |
| Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza. Viral Immunol. 27(10) , 484-96, (2014) Immunopathologic examination of the lungs of mice with experimental influenza virus infection reveals three prominent findings. (i) There is rapidly developing perivascular (arterial) and peribronchia... |
Synonyms
| p-b-Aminoethylphenol |
| P-hydroxy-b-phenylethylamine |
| Z2R DQ |
| MFCD00012682 |
| 4-Hydroxy phenylethylamine |
| EINECS 206-446-4 |
| 4-hydroxy-Benzeneethanamine |
| Phenol, p- (2-aminoethyl)- |
| 4-Hydroxy-β-phenylethylamine |
| 4- (2-aminoethyl)-Phenol |
| p-(2-aminoethyl)-Phenol |
| α-(4-Hydroxyphenyl)-β-aminoethane |
| β-(4-Hydroxyphenyl)ethylamine |
| 2-p-Hydroxyphenylethylamine |
| a-(4-Hydroxyphenyl)-b-aminoethane |
| p-β-Aminoethylphenol |
| 4-hydroxy-phenethylamine |
| p-Hydroxy-β-phenethylamine |
| 4-(2-Aminoethyl)phenol |
| 4-(2-aminoethyl)phenol,hydrochloride |
| b-(4-Hydroxyphenyl)ethylamine |
| Phenol, 4-(2-aminoethyl)- |
| P-hydroxy-β-phenylethylamine |
| Tyramine base |
| P-hydroxy-b-phenethylamine |
