Introduction：Basic information about CAS 142253-56-3|1-Boc-azetidine-3-yl-methanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Boc-azetidine-3-yl-methanol |
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| CAS Number | 142253-56-3 | Molecular Weight | 187.236 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 270.3±13.0 °C at 760 mmHg |
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| Molecular Formula | C9H17NO3 | Melting Point | 55 °C |
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| MSDS | / | Flash Point | 117.3±19.8 °C |
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Names
| Name | 1-Boc-3-azetidinemethanol |
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| Synonym | More Synonyms |
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1-Boc-azetidine-3-yl-methanol BiologicalActivity
| Description | 1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 270.3±13.0 °C at 760 mmHg |
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| Melting Point | 55 °C |
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| Molecular Formula | C9H17NO3 |
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| Molecular Weight | 187.236 |
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| Flash Point | 117.3±19.8 °C |
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| Exact Mass | 187.120850 |
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| PSA | 49.77000 |
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| LogP | 0.01 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.489 |
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| InChIKey | HXRDRJKAEYHOBB-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)N1CC(CO)C1 |
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| Water Solubility | Soluble in Dimethyl sulfoxide (DMSO). |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 23-26-37-60 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-Boc-Azetidine-3-yl-methanol |
| tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate |
| 3-(Hydroxymethyl)azetidine-1-carboxylate |
| 1-(tert-Butoxycarbonyl)-3-azetidinemethanol |
| 1-Boc-3-(hydroxymethyl)azetidine |
