Introduction：Basic information about CAS 23205-42-7|3-Deazauridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-Deazauridine |
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| CAS Number | 23205-42-7 | Molecular Weight | 243.21 |
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| Density | 1.718g/cm3 | Boiling Point | 528ºC at 760mmHg |
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| Molecular Formula | C10H13NO6 | Melting Point | 233-235ºC |
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| MSDS | / | Flash Point | 273.1ºC |
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Names
| Name | 3-Deazauridine |
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| Synonym | More Synonyms |
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3-Deazauridine BiologicalActivity
| Description | 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| Target | Cytidine triphosphate synthase[1] |
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| In Vitro | 3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。 |
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| In Vivo | 3-Deazauridine (DAUR) (250 mg/kg/天；腹腔注射；1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射；给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day，最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day，无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。 |
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| References | [1]. Moriconi WJ, et al. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84. |
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Chemical & Physical Properties
| Density | 1.718g/cm3 |
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| Boiling Point | 528ºC at 760mmHg |
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| Melting Point | 233-235ºC |
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| Molecular Formula | C10H13NO6 |
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| Molecular Weight | 243.21 |
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| Flash Point | 273.1ºC |
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| Exact Mass | 243.07400 |
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| PSA | 112.15000 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.706 |
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| InChIKey | CBOKZNLSFMZJJA-PEBGCTIMSA-N |
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| SMILES | O=c1cc(O)ccn1C1OC(CO)C(O)C1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UV1148000
- CHEMICAL NAME :
- 2(1H)-Pyridone, 4-hydroxy-1-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 23205-42-7
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C10-H13-N-O6
- MOLECULAR WEIGHT :
- 243.24
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 1 nmol
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,295,1983
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Safety Information
Synonyms
| 3-deazauridine |
| EINECS 245-488-8 |
| MFCD00006522 |
