CAS 521-88-0|Karanjin

Introduction：Basic information about CAS 521-88-0|Karanjin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Karanjin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Karanjin
CAS Number	521-88-0	Molecular Weight	292.285
Density	1.4±0.1 g/cm3	Boiling Point	463.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₂O₄	Melting Point	156ºC
MSDS	/	Flash Point	233.8±28.7 °C

Names

Name	3-Methoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one
Synonym	More Synonyms

Karanjin BiologicalActivity

Description	Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis[1][2].
Related Catalog	Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>AMPK
References	[1]. Jaiswal N, et al.Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov 16;670(1):22-8. [2]. Guo JR, et al. Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancercells. Biol Res. 2015 Jul 26;48:40.

Description

Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis[1][2].

Related Catalog

Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>AMPK

References

[1]. Jaiswal N, et al.Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov 16;670(1):22-8.

[2]. Guo JR, et al. Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancercells. Biol Res. 2015 Jul 26;48:40.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	463.0±45.0 °C at 760 mmHg
Melting Point	156ºC
Molecular Formula	C₁₈H₁₂O₄
Molecular Weight	292.285
Flash Point	233.8±28.7 °C
Exact Mass	292.073547
PSA	52.58000
LogP	3.29
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.678
InChIKey	LKPQNZRGGNOPPU-UHFFFAOYSA-N
SMILES	COc1c(-c2ccccc2)oc2c(ccc3occc32)c1=O

Safety Information

Safety Phrases	S22-S24/25
RTECS	DX1500000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Karanjin

4H-Furo[2,3-h]-1-benzopyran-4-one, 3-methoxy-2-phenyl-

3-Methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one

3-Methoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one

3-methoxy-2-phenylfuro[2,3-h]chromen-4-one

MFCD01740600

3-Methoxy-2-phenyl-4H-furo(2,3-h)(1)benzopyran-4-one

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