CAS 609-23-4|2,4,6-Triiodophenol

Introduction：Basic information about CAS 609-23-4|2,4,6-Triiodophenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2,4,6-Triiodophenol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles14
8. Synonyms

Common Name	2,4,6-Triiodophenol
CAS Number	609-23-4	Molecular Weight	471.801
Density	3.1±0.1 g/cm3	Boiling Point	316.3±42.0 °C at 760 mmHg
Molecular Formula	C₆H₃I₃O	Melting Point	157-159 °C(lit.)
MSDS	ChineseUSA	Flash Point	145.1±27.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2,4,6-Triiodophenol
Synonym	More Synonyms

2,4,6-Triiodophenol BiologicalActivity

Description	2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Others
In Vitro	2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers[2]. 2,4,6-Triiodophenol (5 μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos[2]. 2,4,6-Triiodophenol (5-50 μM; 100 h) induces oxidative stress in mouse pre-implantation embryos[2]. Apoptosis Analysis[2] Cell Line: Mouse blastocyst cells Concentration: 5 μM Incubation Time: 85 hours Result: Showed signals of activated Caspase-3/7. Immunofluorescence[2] Cell Line: Mouse blastocyst cells Concentration: 5-50 μM Incubation Time: 100 hours Result: Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol.

Chemical & Physical Properties

Density	3.1±0.1 g/cm3
Boiling Point	316.3±42.0 °C at 760 mmHg
Melting Point	157-159 °C(lit.)
Molecular Formula	C₆H₃I₃O
Molecular Weight	471.801
Flash Point	145.1±27.9 °C
Exact Mass	471.731781
PSA	20.23000
LogP	3.88
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.816
InChIKey	VAPDZNUFNKUROY-UHFFFAOYSA-N
SMILES	Oc1c(I)cc(I)cc1I

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN2800000

CHEMICAL NAME :: Phenol, 2,4,6-triiodo-

CAS REGISTRY NUMBER :: 609-23-4

BEILSTEIN REFERENCE NO. :: 2046861

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H3-I3-O

MOLECULAR WEIGHT :: 471.79

WISWESSER LINE NOTATION :: QR BI DI FI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 18,642,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03493

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H312 + H332-H315-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SN2800000
HS Code	2908199090

Customs

HS Code	2908199090
Summary	HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

Articles14

Distribution of dehalogenation activity in subseafloor sediments of the Nankai Trough subduction zone.

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1616) , 20120249, (2013)

Halogenated organic matter buried in marine subsurface sediment may serve as a source of electron acceptors for anaerobic respiration of subseafloor microbes. Detection of a diverse array of reductive...

Comparative developmental toxicity of new aromatic halogenated DBPs in a chlorinated saline sewage effluent to the marine polychaete Platynereis dumerilii.

Environ. Sci. Technol. 47(19) , 10868-76, (2013)

Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city's sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts...

Fast speciation analysis of iodophenol compounds in river waters by capillary electrophoresis-inductively coupled plasma-mass spectrometry with off-line solid-phase microextraction.

Electrophoresis 25(12) , 1843-51, (2004)

An analytical methodology for the fast separation and determination of iodophenol species in natural water samples was developed using capillary electrophoresis (CE) coupled to inductively coupled pla...

Synonyms

2,6-Triiodophenol

2,4,6-Triiodophenol

Phenol,4,6-triiodo

2,4,6-Trijodfenol

triiodo-2,4,6 phenol

2,3-DIHYDROXYL QUINOXALINE

Phenol, 2,4,6-triiodo-

Phenol,2,4,6-triiodo

EINECS 210-186-7

2,4,6-Trijodfenol [Czech]

2,4,6-triIPhOH

MFCD00002179

2,4,6-triiodo-phenol

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