CAS 74431-23-5|Imipenem

Introduction：Basic information about CAS 74431-23-5|Imipenem, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Imipenem BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles13
6. Synonyms

Common Name	Imipenem
CAS Number	74431-23-5	Molecular Weight	317.36
Density	1.02 g/mL at 25 °C	Boiling Point	34.6°C
Molecular Formula	C₁₂H₁₉N₃O₅S	Melting Point	-116.3°C
MSDS	USA	Flash Point	<−30 °F

Names

Name	imipenem hydrate
Synonym	More Synonyms

Imipenem BiologicalActivity

Description	Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Zhanel GG, et al. Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects. Can J Infect Dis. 1998 Jul;9(4):215-28. [2]. Jacoby GA, et al. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82. [3]. Balibar CJ, et al. cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology. 2010 May;156(Pt 5):1372-83.

Description

Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Zhanel GG, et al. Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects. Can J Infect Dis. 1998 Jul;9(4):215-28.

[2]. Jacoby GA, et al. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82.

[3]. Balibar CJ, et al. cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology. 2010 May;156(Pt 5):1372-83.

Chemical & Physical Properties

Density	1.02 g/mL at 25 °C
Boiling Point	34.6°C
Melting Point	-116.3°C
Molecular Formula	C₁₂H₁₉N₃O₅S
Molecular Weight	317.36
Flash Point	<−30 °F
Exact Mass	317.104553
PSA	148.25000
LogP	0.18820
InChIKey	GSOSVVULSKVSLQ-JJVRHELESA-N
SMILES	CC(O)C1C(=O)N2C(C(=O)O)=C(SCCN=CN)CC12.O
Storage condition	-20°C Freezer

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+,C,F
Risk Phrases	R12:Extremely Flammable. R14/15:Reacts violently with water, liberating extremely flammable gases . R19:May form explosive peroxides. R22:Harmful if swallowed. R34:Causes burns. R66:Repeated exposure may cause skin dryness or cracking. R67:Vapors may cause
Safety Phrases	S16-S26-S36/37/39-S43-S45-S7/8-S27
RIDADR	UN 3399 4.3/PG 1
WGK Germany	1
Packaging Group	I
Hazard Class	4.3

Articles13

Combined disc methods for the detection of KPC- and/or VIM-positive Klebsiella pneumoniae: improving reliability for the double carbapenemase producers.

Clin. Microbiol. Infect. 19(9) , E412-5, (2013)

Klebsiella pneumoniae strains co-producing klebsiella pneumoniae carbapenemase (KPC) and verona integron-encoded metallo-beta-lactamase (VIM) are frequently isolated in Greece and have also occurred i...

Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.

Biol. Pharm. Bull. 38 , 1425-9, (2015)

The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from ...

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.

J. Antimicrob. Chemother. 70 , 1434-42, (2015)

Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize ...

Synonyms

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, hydrate (1:1)

(5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid monohydrate

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäurehydrat

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1)

Imipenem hydrate

N-Formimidoylthienamycin Monohydrate

MFCD08458212

Imipenem monohydrate

Imipenem, Monohydrate

EINECS 264-734-5

1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, monohydrate

acide (5R,6S)-6-[(1R)-1-hydroxyéthyl]-3-({2-[(iminométhyl)amino]éthyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ène-2-carboxylique hydrate

[5R-[5a,6a(R*)]]-6-(1-Hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Monohydrate

(5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

Imipenem

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