CAS 23964-58-1|Articaine
Introduction：Basic information about CAS 23964-58-1|Articaine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Articaine | ||
|---|---|---|---|
| CAS Number | 23964-58-1 | Molecular Weight | 284.37500 |
| Density | 1.178 g/cm3 | Boiling Point | 440.6ºC at 760 mmHg |
| Molecular Formula | C13H20N2O3S | Melting Point | / |
| MSDS | / | Flash Point | 220.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate |
|---|---|
| Synonym | More Synonyms |
Articaine BiologicalActivity
| Description | Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelSignaling Pathways >>Immunology/Inflammation >>NOD-like Receptor (NLR)Research Areas >>Inflammation/Immunology |
| Target | NF-ĸB, NLRP3, sodium channel[2][3] |
| References | [1]. Yapp KE, et al. Articaine: a review of the literature. Br Dent J. 2011 Apr 9;210(7):323-9. [2]. Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. [3]. Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local Reg Anesth. 2012;5:23-33. |
Chemical & Physical Properties
| Density | 1.178 g/cm3 |
|---|---|
| Boiling Point | 440.6ºC at 760 mmHg |
| Molecular Formula | C13H20N2O3S |
| Molecular Weight | 284.37500 |
| Flash Point | 220.3ºC |
| Exact Mass | 284.11900 |
| PSA | 95.67000 |
| LogP | 2.63360 |
| Vapour Pressure | 5.79E-08mmHg at 25°C |
| Index of Refraction | 1.556 |
| InChIKey | QTGIAADRBBLJGA-UHFFFAOYSA-N |
| SMILES | CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
Synonyms
| 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester |
| Carticaine |
| Articainum [INN-Latin] |
| Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat) |
| Articaina [INN-Spanish] |
| 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene |
| Articaine |
| Articainum |
| Hoe-045 |
| MFCD00190157 |
| Articaina |
