CAS 94-25-7|butamben
Introduction：Basic information about CAS 94-25-7|butamben, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | butamben | ||
|---|---|---|---|
| CAS Number | 94-25-7 | Molecular Weight | 193.242 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 325.7±0.0 °C at 760 mmHg |
| Molecular Formula | C11H15NO2 | Melting Point | 57-58 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 184.6±17.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | butamben |
|---|---|
| Synonym | More Synonyms |
butamben BiologicalActivity
| Description | Butamben is a long-duration local anesthetic used for the treatment of chronic pain. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelResearch Areas >>Neurological Disease |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 325.7±0.0 °C at 760 mmHg |
| Melting Point | 57-58 °C(lit.) |
| Molecular Formula | C11H15NO2 |
| Molecular Weight | 193.242 |
| Flash Point | 184.6±17.9 °C |
| Exact Mass | 193.110275 |
| PSA | 52.32000 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.540 |
| InChIKey | IUWVALYLNVXWKX-UHFFFAOYSA-N |
| SMILES | CCCCOC(=O)c1ccc(N)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 67 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,900,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81345 No. of Facilities: 334 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 11589 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81345 No. of Facilities: 777 (estimated) No. of Industries: 2 No. of Occupations: 13 No. of Employees: 49619 (estimated) No. of Female Employees: 42223 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H317-H319-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38;R43 |
| Safety Phrases | S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DG1530000 |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
Articles25
More Articles| Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben. Neurosci. Lett. 506(2) , 297-302, (2012) Butamben (n-butyl-p-aminobenzoic acid) is a pain-relieving local anesthetic for topical use. Blockade of voltage-gated channel expressed in the peripheral sensory neurons has been suggested as a mecha... | |
| Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression. Bioorg. Med. Chem. Lett. 21 , 7363-6, (2011) As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the pres... | |
| Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J. Biol. Chem. 277(46) , 43691-7, (2002) The Xenopus benzoate nuclear hormone receptors, BXRalpha and BXRbeta, share 82% identity within their ligand-binding domains and are classified as members of the NR1I2 subfamily that includes the mamm... |
Synonyms
| Butesin |
| MFCD00017112 |
| Butyl aminobenzoate |
| n-butyl 4-aminobenzoate |
| Butesine |
| 4-Aminobenzoic acid butyl ester |
| N-Butyl p-aminobenzoate |
| Scuroforme |
| Butyl p-aminobenzoate |
| Butyl 4-aminobenzoate |
| p-amino-benzoic acid butyl ester |
| Butylcaine |
| Benzoic acid, 4-amino-, butyl ester |
| Butamben (USP) |
| Scuroform |
| Planoform |
| butamben |
| Butoform |
| butyl ester of p-aminobenzoic acid |
| EINECS 202-317-1 |
